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Titolo:
Effect of the apolipoprotein A-IV Q360H polymorphism on postprandial plasma triglyceride clearance
Autore:
Hockey, KJ; Anderson, RA; Cook, VR; Hantgan, RR; Weinberg, RB;
Indirizzi:
Wake Forest Univ, Bowman Gray Sch Med, Dept Internal Med, Gastroenterol Sect, Winston Salem, NC 27157 USA Wake Forest Univ Winston Salem NC USA 27157 , Winston Salem, NC 27157 USA Wake Forest Univ, Bowman Gray Sch Med, Dept Biochem, Winston Salem, NC 27157 USA Wake Forest Univ Winston Salem NC USA 27157 , Winston Salem, NC 27157 USA
Titolo Testata:
JOURNAL OF LIPID RESEARCH
fascicolo: 2, volume: 42, anno: 2001,
pagine: 211 - 217
SICI:
0022-2275(200102)42:2<211:EOTAAQ>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIETARY-FAT CLEARANCE; B SIGNAL PEPTIDE; GENETIC-VARIATION; LIPOPROTEIN-LIPASE; RICH LIPOPROTEINS; LIPID-METABOLISM; III HYPERLIPOPROTEINEMIA; INTESTINAL LIPOPROTEINS; NORMOLIPIDEMIC CARRIERS; DELETION POLYMORPHISM;
Keywords:
genetic polymorphisms; low density lipoproteins; high density lipoproteins; saturated fat; polyunsaturated fat; apolipoprotein E;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Weinberg, RB Wake Forest Univ, Bowman Gray Sch Med, Dept Internal Med, Gastroenterol Sect, Winston Salem, NC 27157 USA Wake Forest Univ Winston Salem NC USA 27157 em, NC 27157 USA
Citazione:
K.J. Hockey et al., "Effect of the apolipoprotein A-IV Q360H polymorphism on postprandial plasma triglyceride clearance", J LIPID RES, 42(2), 2001, pp. 211-217

Abstract

Apolipoprotein (apo)A-IV is synthesized in the small intestine during fat absorption and is incorporated onto the surface of nascent chylomicrons, Incirculation, apoA-IV is displaced from the chylomicron surface by high density lipoprotein-associated C and E apolipoproteins; this exchange is critical for activation of lipoprotein lipase and chylomicron remnant clearance,The variant allele A-IV-2 encodes a Q360H polymorphism that increases the lipid affinity of the apoA-IV-2 isoprotein. We hypothesized that this wouldimpede the transfer of C and E apolipoproteins to chylomicrons, and thereby delay the clearance of postprandial triglyceride-rich lipoproteins. We therefore measured triglycerides in plasma, S-f > 400 chylomicrons, and very low density lipoproteins (VLDL) in 14 subjects heterozygous for the A-IV-2 allele (1/2) and 14 subjects homozygous for the common allele (1/1) who were fed a standard meal containing 50 gm fat per m(2) body surface area. All subjects had the apoE-3/3 genotype, Postprandial triglyceride concentrations in the 1/2 subjects were significantly higher between 2-5 h in plasma, chylomicrons, and VLDL, and peaked at 3 h versus 2 h for the 1/1 subjects. The area under the triglyceride time curves was greater in the 1/2 subjects (plasma, P = 0.045; chylomicrons, P = 0.027; VLDL, P = 0.063). A post-hoc analysis of the frequency of the apoA-IV T347S polymorphism suggested that ithad an effect on triglyceride clearance antagonistic to that of the A-IV-2allele. We conclude that individuals heterozygous for the A-IV-2 allele display delayed postprandial clearance of triglyceride-rich lipoproteins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/08/20 alle ore 02:15:09