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Titolo:
Angiotensin II type 1 receptor (-153)A/G and (1166)A/C gene polymorphisms and increase in aortic stiffness with age in hypertensive subjects
Autore:
Lajemi, M; Labat, C; Gautier, S; Lacolley, P; Safar, M; Asmar, R; Cambien, F; Benetos, A;
Indirizzi:
Inst Cordeliers, INSERM, U337, F-75006 Paris, France Inst Cordeliers Paris France F-75006 INSERM, U337, F-75006 Paris, France INSERM, U525, F-75013 Paris, France INSERM Paris France F-75013INSERM, U525, F-75013 Paris, France
Titolo Testata:
JOURNAL OF HYPERTENSION
fascicolo: 3, volume: 19, anno: 2001,
pagine: 407 - 413
SICI:
0263-6352(200103)19:3<407:AIT1R(>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH BLOOD-PRESSURE; CONVERTING-ENZYME; MYOCARDIAL-INFARCTION; PULSE PRESSURE; VASCULAR REACTIVITY; ARTERIAL STIFFNESS; ELASTIC PROPERTIES; POPULATION; PREDICTOR; MORTALITY;
Keywords:
genetics; angiotensin II type 1 receptor; aldosterone synthase; stiffness; arterial ageing;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Benetos, A Inst Cordeliers, INSERM, U337, 15 Rue Ecole Med, F-75006 Paris,France Inst Cordeliers 15 Rue Ecole Med Paris France F-75006 , France
Citazione:
M. Lajemi et al., "Angiotensin II type 1 receptor (-153)A/G and (1166)A/C gene polymorphisms and increase in aortic stiffness with age in hypertensive subjects", J HYPERTENS, 19(3), 2001, pp. 407-413

Abstract

Objectives Arterial stiffness is associated with excess morbidity and mortality, independently of other cardiovascular risk factors. Age is the main determinant responsible for arterial wall changes leading to arterial stiffening. Environmental and genetic factors may however influence the magnitude of the effects of age on large artery stiffness,Design and methods The present study assessed whether or not the relationship between age and aortic stiffness was influenced by genetic variants of angiotensinogen (AGT T-174/M, M-235/T), angiotensin converting enzyme (ACE I/D), angiotensin II type 1 receptor(AT(1) (1166)A/C, (-153)A/G) and aldosterone synthase (CYP11B(2) T-344/C). This study was realized in 441 untreated hypertensive subjects of European origin (aged 18-74 years). Aortic stiffness was assessed by carotid-femoral pulse wave velocity (PWV),Results Carriers of the angiotensin II type 1 receptor (-153)G allele showed a steeper age/PWV relationship than the AT(1) (-153)AA subjects. The effect of the AT(1) (-153)A/G polymorphism on aortic stiffness became apparentafter the age of 55 years, In subjects with the AT(1) C-1166 allele, the relationship age/PWV is shifted upward, indicating higher values of aortic stiffness at any age compared to the A(1) (1166)AA patients, Carriers of both the AT(1) C-1166 and (-153)G alleles presented the additive effects of these 2 genotypes on aortic stiffness, Angiotensinogen, ACE and CYP11 B-2 genotypes did not influence the effects of age on PWV,Conclusions AT(1) receptor genotypes could influence arterial ageing in hypertensive subjects. These results also show that the association between genotypes and arterial stiffness may manifest itself later in life. J Hypertens 19:407-413 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 18:01:45