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Titolo:
The anti-inflammatory effects of human recombinant copper-zinc superoxide dismutase on pulp inflammation
Autore:
Baumgardner, KR; Sulfaro, MA;
Indirizzi:
Univ Michigan, Sch Dent, Dept Cariol Restorat Sci & Endodont, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 & Endodont, Ann Arbor, MI 48109 USA
Titolo Testata:
JOURNAL OF ENDODONTICS
fascicolo: 3, volume: 27, anno: 2001,
pagine: 190 - 195
SICI:
0099-2399(200103)27:3<190:TAEOHR>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; TOOTH PREPARATION; RAT PULP; IMMUNOREACTIVITY; LOCALIZATION; INJURY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Baumgardner, KR Univ Michigan, Sch Dent, Dept Cariol Restorat Sci & Endodont, 1011 N Univ,Ann Arbor, MI 48109 USA Univ Michigan 1011 N Univ Ann ArborMI USA 48109 48109 USA
Citazione:
K.R. Baumgardner e M.A. Sulfaro, "The anti-inflammatory effects of human recombinant copper-zinc superoxide dismutase on pulp inflammation", J ENDODONT, 27(3), 2001, pp. 190-195

Abstract

Inflammation in the dental pulp is accompanied by release of a wide variety of highly oxidative molecules known as reactive oxygen species (ROS), ROSconcentrations are controlled in vivo by an antioxidant enzyme scavenger system that may be overwhelmed by the increases in ROS production seen during inflammation. Supplementation of the antioxidant defense system, therefore, may limit the severity of the inflammatory response to injury due to this component. To test this hypothesis, this study examined the effects of superoxide radical scavenging on pulpal inflammation induced in rat molars bystandardized cavity preparation. The extent of pulp inflammation was compared histomorphometrically between animals treated with exogenous administration of a human recombinant antioxidant enzyme, copper-zinc superoxide dismutase, conjugated to polyethylene glycol (hrCuZn-SOD), versus saline-vehicle controls. There was a statistically significant reduction in area of inflammation involvement in those animals treated with hrCuZn-SOD, compared with controls. Although hrCuZn-SOD administration did not completely eliminateinflammation in all animals treated, there was a statistically significantlessening of the severity of the inflammatory response, as well as a greater degree of reparative dentin observed in the hrCuZn-SOD-treated animals.

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Documento generato il 13/07/20 alle ore 11:04:02