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Titolo:
Switching versus augmentation: A prospective, naturalistic comparison in depressed, treatment-resistant patients
Autore:
Posternak, MA; Zimmerman, M;
Indirizzi:
Brown Univ, Rhode Isl Hosp, Sch Med, Dept Psychiat & Human Behav, Providence, RI 02905 USA Brown Univ Providence RI USA 02905 Human Behav, Providence, RI 02905 USA
Titolo Testata:
JOURNAL OF CLINICAL PSYCHIATRY
fascicolo: 2, volume: 62, anno: 2001,
pagine: 135 - 142
SICI:
0160-6689(200102)62:2<135:SVAAPN>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
TREATMENT-REFRACTORY DEPRESSION; LITHIUM-CARBONATE AUGMENTATION; SEROTONIN REUPTAKE INHIBITORS; PLACEBO-CONTROLLED TRIAL; DOUBLE-BLIND; MAJOR DEPRESSION; TRICYCLIC ANTIDEPRESSANTS; ENDOGENOUS-DEPRESSION; UNIPOLAR DEPRESSION; FLUOXETINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Posternak, MA Brown Univ, Rhode Isl Hosp, Sch Med, Dept Psychiat & Human Behav, 235 Plain St,Suite 501, Providence, RI 02905 USA Brown Univ 235 PlainSt,Suite 501 Providence RI USA 02905 SA
Citazione:
M.A. Posternak e M. Zimmerman, "Switching versus augmentation: A prospective, naturalistic comparison in depressed, treatment-resistant patients", J CLIN PSY, 62(2), 2001, pp. 135-142

Abstract

Objective: (1) To directly compare the effectiveness of switching antidepressants with augmenting them in depressed patients who do not respond to aninitial adequate trial and (2) to determine whether there is a decreased likelihood of response to a second switch or augmentation trial in those patients who did not respond to the first intervention for treatment-resistantdepression,Method: In a naturalistic, open-label design, all depressed outpatients (DSM-IV criteria) who were treatment resistant were prospectively assessed. Short- and long-term outcomes of switching versus augmentation were comparedusing the Clinical Global Impressions scale. Results: In the acute phase, 37 (50.0%) of 74 subjects responded to 1 of the 2 interventions for treatment-resistant depression. Forty-five percent (N = 17) and 56% (N = 20) of the patients who had their antidepressant switched or augmented, respectively, responded to that intervention. Nearly three fourths (71.4%) of the acute responders maintained their response through6 months of follow-up. In 18 patients who did not respond to the first switch or augmentation, 9 (50.0%) responded to a second trial. Conclusion: Switching antidepressants was somewhat less effective than augmentation, although this difference was not statistically significant. For patients who do not respond to an augmentation or switch, our results suggest that a second trial for treatment-resistant depression may be as effective as the first.

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Documento generato il 19/01/20 alle ore 20:03:32