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Titolo:
Expression of killer cell inhibitory receptors is restricted to true NK cell lymphomas and a subset of intestinal enteropathy-type T cell lymphomas with a cytotoxic phenotype
Autore:
Dukers, DF; Vermeer, MH; Jaspars, LH; Sander, CA; Flaig, MJ; Vos, W; Willemze, R; Meijer, CJLM;
Indirizzi:
Vrije Univ Amsterdam, Dept Pathol, NL-1081 HV Amsterdam, Netherlands VrijeUniv Amsterdam Amsterdam Netherlands NL-1081 HV erdam, Netherlands Vrije Univ Amsterdam, Dept Dermatol, NL-1081 HV Amsterdam, Netherlands Vrije Univ Amsterdam Amsterdam Netherlands NL-1081 HV erdam, Netherlands Univ Munich, Dept Dermatol, D-080337 Munich, Germany Univ Munich Munich Germany D-080337 t Dermatol, D-080337 Munich, Germany
Titolo Testata:
JOURNAL OF CLINICAL PATHOLOGY
fascicolo: 3, volume: 54, anno: 2001,
pagine: 224 - 228
SICI:
0021-9746(200103)54:3<224:EOKCIR>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CATALYZED REPORTER DEPOSITION; REED-STERNBERG CELLS; HODGKINS-DISEASE; GRANZYME-B; SIGNAL AMPLIFICATION; LYMPHOCYTES-T; MOLECULES; CLASSIFICATION; IMMUNOASSAYS; PROTEINS;
Keywords:
lymphoma; granzyme B; killer inhibitory receptors; CD94;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Dukers, DF Vrije Univ Amsterdam, Dept Pathol, De Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands Vrije Univ Amsterdam De Boelelaan 1117 Amsterdam Netherlands NL-1081 HV
Citazione:
D.F. Dukers et al., "Expression of killer cell inhibitory receptors is restricted to true NK cell lymphomas and a subset of intestinal enteropathy-type T cell lymphomas with a cytotoxic phenotype", J CLIN PATH, 54(3), 2001, pp. 224-228

Abstract

Background/Aims-Killer inhibitory receptors (KIR) have a modulating effecton the cytotoxic functions of natural killer (NK) cells and T cells. Because lymphoma cells often have the same receptors as their non-neoplastic counterparts, this study investigated the expression of KIR on well defined groups of NK and T cell lymphomas, with and without a cytotoxic phenotype, from different sites of origin. Methods-Nine CD56(+)/CD3(-) NK cell lymphomas, 29 CD3(+)/CD56(-) T cell lymphomas with a cytotoxic phenotype, and 19 T cell lymphomas without a cytotoxic phenotype were stained for KIR using monoclonal antibodies specific for CD94, CD158a, and CD158b. In addition, the expression of KIR was studied on normal lymphoid tissues. Results-KIR expression was seen in five of nine true NK cell lymphomas including three of four nasal, one of four cutaneous, and one of one intestinal lymphoma nasal type. Double staining for CD56 and CD94 in normal lymphoidtissues revealed that KIR was predominantly expressed by CD56(+) NK cells and sporadically on CD8(+) T cells. Moreover, enteropathy-type T cell lymphomas with a cytotoxic phenotype showed KIR expression (three cases expressing CD94 and one case expressing CD158a). All nodal and extranodal non-intestinal T cell lymphomas with or without a cytotoxic phenotype lacked expression of KIR. Conclusions-These results show that KIR expression is restricted to CD56(+)/CD3(-) true NK cell lymphomas originating from the nose, gut, and skin, as well as in a subset of extranodal T cell lymphomas originating from the small intestine, which possessed a cytotoxic phenotype. Thus, the presence of KIR on NK/T cell lymphomas seems to mimic the distribution of KIR found on NK and T cells in normal lymphoid tissue.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 04:28:24