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Titolo:
KIDNEYS FROM NORMOTENSIVE DONORS LOWER BLOOD-PRESSURE IN YOUNG TRANSPLANTED SPONTANEOUSLY HYPERTENSIVE RATS
Autore:
PATSCHAN O; KUTTLER B; HEEMANN U; UBER A; RETTIG R;
Indirizzi:
UNIV GREIFSWALD,DEPT PHYSIOL,RUBENOWSTR 3 D-17487 GREIFSWALD GERMANY UNIV GREIFSWALD,DEPT PHYSIOL D-17487 GREIFSWALD GERMANY DIABET RES INST D-17495 KARLSBURG GERMANY UNIV ESSEN GESAMTHSCH,DEPT MED D-45122 ESSEN GERMANY
Titolo Testata:
American journal of physiology. Regulatory, integrative and comparative physiology
fascicolo: 1, volume: 42, anno: 1997,
pagine: 175 - 180
SICI:
0363-6119(1997)42:1<175:KFNDLB>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLOSPORINE-INDUCED HYPERTENSION; RENAL-TRANSPLANTATION; NEPHROTOXICITY; RECIPIENTS; TOLERANCE;
Keywords:
BIOBREEDING OTTAWA KARLSBURG RATS; HYPERTENSION; RENAL TRANSPLANTATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
O. Patschan et al., "KIDNEYS FROM NORMOTENSIVE DONORS LOWER BLOOD-PRESSURE IN YOUNG TRANSPLANTED SPONTANEOUSLY HYPERTENSIVE RATS", American journal of physiology. Regulatory, integrative and comparative physiology, 42(1), 1997, pp. 175-180

Abstract

Single transplanted kidneys from spontaneously hypertensive rats (SHR) have been shown to elicit hypertension in genetically normotensive recipients. This study was designed to investigate the effects of single transplanted kidneys from genetically normotensive donors [Biobreeding (BB)/Ottawa Karlsburg (OK) rats] on blood pressure in SHR recipients. The following groups were formed: group 1 (n = 11), SHR donors and SHR recipients; group 2 (n = 15), BB/OK donors and SHR recipients; andgroup 3 (n = 8), BE/OK donors and BE/OK recipients. Recipients received antihypertensive treatment (hydralazine) from weaning until renal transplantation at the age of 9 wk and immunosuppressive treatment (anti-CD4 antibody and cyclosporine A) for 3 wk starting on the day of transplantation. Six weeks after transplantation, intraarterially measured blood pressure and heart weight-to-body weight ratio were highest ingroup 1, intermediate ingroup 2, and lowest in group 3. There were nosignificant differences with respect to plasma urea and creatinine concentrations among the three groups. These results support the hypothesis that hypertension in renal-transplanted SHR depends in part on thegenetic background of the transplanted kidney.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 07:06:29