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Titolo:
Skeletal muscle cell activation by low-energy laser irradiation: A role for the MAPK/ERK pathway
Autore:
Shefer, G; Oron, U; Irintchev, A; Wernig, A; Halevy, O;
Indirizzi:
Hebrew Univ Jerusalem, Dept Anim Sci, IL-76100 Rehovot, Israel Hebrew UnivJerusalem Rehovot Israel IL-76100 , IL-76100 Rehovot, Israel Tel Aviv Univ, George S Wise Fac Life Sci, Dept Zool, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 t Zool, IL-69978 Tel Aviv, Israel Univ Bonn, Dept Physiol, D-5300 Bonn, Germany Univ Bonn Bonn Germany D-5300 v Bonn, Dept Physiol, D-5300 Bonn, Germany
Titolo Testata:
JOURNAL OF CELLULAR PHYSIOLOGY
fascicolo: 1, volume: 187, anno: 2001,
pagine: 73 - 80
SICI:
0021-9541(200104)187:1<73:SMCABL>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE PATHWAY; IN-VITRO; SATELLITE CELLS; GASTROCNEMIUS-MUSCLE; SIGNAL-TRANSDUCTION; CALCIUM-TRANSPORT; SMOOTH-MUSCLE; FACTOR-ALPHA; CYCLIN D1; MITOGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Halevy, O Hebrew Univ Jerusalem, Dept Anim Sci, POB 12, IL-76100 Rehovot, Israel Hebrew Univ Jerusalem POB 12 Rehovot Israel IL-76100 ot, Israel
Citazione:
G. Shefer et al., "Skeletal muscle cell activation by low-energy laser irradiation: A role for the MAPK/ERK pathway", J CELL PHYS, 187(1), 2001, pp. 73-80

Abstract

Low-energy laser irradiation (LELI) has been shown to promote skeletal muscle regeneration in vivo and to activate skeletal muscle satellite cells, enhance their proliferation and inhibit differentiation in vitro. In the present study, LELI, as well as the addition of serum to serum-starved myoblasts, restored their proliferation, whereas myogenic differentiation remainedlow. LELI induced mitogen-activated protein kinase/extracellular signal-regulated protein kinase (MAPK/ERK) phosphorylation with no effect on its expression in serum-starved myoblasts. Moreover, a specific MAPK kinase inhibitor (PD098059) inhibited the LELI- and 10% serum-mediated ERK1/2 activation. However, LELI did not affect jun N-terminal kinase (JNK) or p38 MAPK phosphorylation or protein expression. Whereas a 3-sec irradiation induced ERK1/2 phosphorylation, a 12-sec irradiation reduced it, again with no effect on JNK or p38. Moreover. LELI had distinct effects on receptor phosphorylation: it caused phosphorylation of the hepatocyte growth factor (HGF) receptor, previously shown to activate the MAPK/ERK pathway, whereas no effect wasobserved on tumor suppressor necrosis alpha (TNF-alpha) receptor which activates the p38 and JNK pathways. Therefore, by specifically activating MAPK/ERK, but not INK and p38 MAPK enzymes, probably by specific receptor phosphorylation. LELI induces the activation and proliferation of quiescent satellite cells and delays their differentiation. (C) 2001 Wiley-Liss Inc.

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Documento generato il 28/03/20 alle ore 23:16:27