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Titolo:
CONTRIBUTION OF HUMORAL SYSTEMS TO THE SHORT-TERM VARIABILITY OF BLOOD-PRESSURE AFTER SEVERE HEMORRHAGE
Autore:
PONCHON P; ELGHOZI JL;
Indirizzi:
FAC MED NECKER ENFANTS MALAD,CNRS,URA 1482,PHARMACOL LAB,156 RUE VAUGIRARD F-75015 PARIS FRANCE
Titolo Testata:
American journal of physiology. Regulatory, integrative and comparative physiology
fascicolo: 1, volume: 42, anno: 1997,
pagine: 58 - 69
SICI:
0363-6119(1997)42:1<58:COHSTT>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPECTRAL-ANALYSIS APPROACH; HEART-RATE; ARTERIAL-PRESSURE; CONSCIOUS RATS; HEMODYNAMIC ANALYSIS; NERVOUS-SYSTEM; OSCILLATIONS; DOGS; RESPIRATION; MODULATION;
Keywords:
SPECTRAL ANALYSIS; ANGIOTENSIN II; VASOPRESSIN; CATECHOLAMINES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
P. Ponchon e J.L. Elghozi, "CONTRIBUTION OF HUMORAL SYSTEMS TO THE SHORT-TERM VARIABILITY OF BLOOD-PRESSURE AFTER SEVERE HEMORRHAGE", American journal of physiology. Regulatory, integrative and comparative physiology, 42(1), 1997, pp. 58-69

Abstract

The aim of this study was to generate hemorrhage-triggered fluctuations in blood pressure (BP) at low frequency (LF, <0.2 Hz) in conscious rats and investigate with spectral analysis the relative roles of hemorrhage-activated catecholamines, the renin-angiotensin system (RAS), and arginine vasopressin (AVP) on the generation of these fluctuations. The individual contribution of these factors was assessed using a combination of the selective antagonists, prazosin, losartan, and Manningcompound (AVPX). At rest, systolic BP (SEP) LF fluctuations were slightly increased by losartan. The mid-frequency (MF; 0.2-0.6 Hz) oscillations of SEP and diastolic BP (DBP) were decreased by prazosin alone or associated with AVPX or losartan. The high-frequency (HF; respiratory) oscillations of SEP were increased by prazosin, prazosin plus losartan, and prazosin plus AVPX. After severe hemorrhage (20 ml/kg), the spontaneous BP recovery was characterized by the occurrence of slow fluctuations of SEP and DBP, centered similar to 0.065 Hz, and by increases of MF (89%) oscillations of SEP. The HF component of SEP variability tended to be increased by blood loss. The occurrence of the SEP LF fluctuations was prevented when al-adrenergic activity was blocked by prazosin. These oscillations mere always present, despite inhibition ofangiotensin II, and were increased after inhibition of the AVP activity. Pretreat;ment with the specific inhibitors used in these studies favored the amplifying effect of hemorrhage on HF fluctuations while they prevented the postbleeding increase in MF oscillations. In conclusion, the present results show an association between the dependence of the postbleeding blood pressure level on catecholamines and the occurrence of slow fluctuations of BP. The buffering role of AVP suggests the establishment of a hierarchy between humoral systems in the genesis of the LF oscillations of BP, with the slow oscillations being generated by the main presser system and being dampened by the other systems. The postbleeding rise in the MF component of SEP variability could beconsidered a reflection of the activations of both the sympathetic vasomotor drive and the RAS. The postbleeding increase in the HF component of BP variability was dampened by the activation of the humoral systems. These effects may reflect the low preload state due to hypovolemia.

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Documento generato il 24/11/20 alle ore 14:33:16