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Titolo:
Involvement of ResE phosphatase activity in down-regulation of ResD-controlled genes in Bacillus subtilis during aerobic growth
Autore:
Nakano, MM; Zhu, Y;
Indirizzi:
Oregon Grad Inst Sci & Technol, Dept Biochem & Mol Biol, Beaverton, OR 97006 USA Oregon Grad Inst Sci & Technol Beaverton OR USA 97006 erton, OR 97006 USA
Titolo Testata:
JOURNAL OF BACTERIOLOGY
fascicolo: 6, volume: 183, anno: 2001,
pagine: 1938 - 1944
SICI:
0021-9193(200103)183:6<1938:IORPAI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
2-COMPONENT SIGNAL-TRANSDUCTION; ESCHERICHIA-COLI; RESPONSE REGULATOR; OXYGEN LIMITATION; ANAEROBIC GROWTH; PHOSPHOTRANSFER; IDENTIFICATION; EXPRESSION; ENVZ; AUTOPHOSPHORYLATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Nakano, MM Oregon Grad Inst Sci & Technol, Dept Biochem & Mol Biol, 20000 NW Walker Rd, Beaverton, OR 97006 USA Oregon Grad Inst Sci & Technol 20000 NW Walker Rd Beaverton OR USA 97006
Citazione:
M.M. Nakano e Y. Zhu, "Involvement of ResE phosphatase activity in down-regulation of ResD-controlled genes in Bacillus subtilis during aerobic growth", J BACT, 183(6), 2001, pp. 1938-1944

Abstract

The ResD-ResE signal transduction system is required for aerobic and anaerobic respiration in Bacillus subtilis. The histidine sensor kinase ResE, byfunctioning as a kinase and a phosphatase for the cognate response regulator ResD, controls the level of phosphorylated ResD. A high level of phosphorylated ResD is postulated to cause a dramatic increase in transcription ofResDE-controlled genes under anaerobic renditions. A mutant ResE, which retains autophosphorylation and ResD phosphorylation activities but is defective in ResD dephosphorylation, allowed partially derepressed aerobic expression of the ResDE-controlled genes. The result indicates that phosphatase activity of ResE is regulated by oxygen availability and anaerobic inductionof the ResDE regulon is partly due to a reduction of the ResE phosphatase activity during anaerobiosis. That elimination of phosphatase activity doesnot result in complete aerobic derepression suggests that the ResE kinase activity is also subject to control in response to oxygen limitation.

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Documento generato il 23/11/20 alle ore 21:47:10