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Titolo:
Saliva testing after single and chronic administration of dihydrocodeine
Autore:
Skopp, G; Potsch, L; Klinder, K; Richter, B; Aderjan, R; Mattern, R;
Indirizzi:
Univ Heidelberg, Inst Rechtsmed & Verkehrsmed, D-69115 Heidelberg, GermanyUniv Heidelberg Heidelberg Germany D-69115 , D-69115 Heidelberg, Germany Univ Mainz, Inst Rechts Med, D-55131 Mainz, Germany Univ Mainz Mainz Germany D-55131 Inst Rechts Med, D-55131 Mainz, Germany Psychiat Zentrum Nordbaden, D-69168 Wiesloch, Germany Psychiat Zentrum Nordbaden Wiesloch Germany D-69168 68 Wiesloch, Germany
Titolo Testata:
INTERNATIONAL JOURNAL OF LEGAL MEDICINE
fascicolo: 3, volume: 114, anno: 2001,
pagine: 133 - 140
SICI:
0937-9827(200102)114:3<133:STASAC>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
DRUGS; CODEINE; ABUSE; COCAINE; DISPOSITION; PLASMA; FLUIDS; URINE; SERUM; SWEAT;
Keywords:
saliva testing; dihydrocodeine metabolites; single low-dose administration; chronic high-dosage administration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Skopp, G Univ Heidelberg, Inst Rechtsmed & Verkehrsmed, Vossstr 2, D-69115Heidelberg, Germany Univ Heidelberg Vossstr 2 Heidelberg Germany D-69115 rg, Germany
Citazione:
G. Skopp et al., "Saliva testing after single and chronic administration of dihydrocodeine", INT J LEGAL, 114(3), 2001, pp. 133-140

Abstract

In the present study, concentrations of dihydrocodeine and its metabolitesin saliva and serum were compared after single low-dose and chronic high-dosage administration of the drug. In the first investigation, blood and saliva were collected periodically from six subjects after oral administrationof 60 mg dihydrocodeine. In the second study, 20 subjects on oral dihydrocodeine maintenance provided single samples of blood and saliva simultaneously. Serum protein binding of salivary analytes and their recovery from the adsorbing material of the collection device as well as pH values of saliva samples were determined. The fluids were analyzed for dihydrocodeine and the major metabolites by high-performance liquid chromatography. In the single dose study dihydrocodeine was the only analyte found in saliva for up to 12-24 h post-dose. The half-life of dihydrocodeine in saliva was about twice that found in blood. The ratios of salival serum concentrations ranged from 1.2 to 17.0. After chronic high-dosage use, dihydrocodeine was the main salivary analyte and N-nordihydrocodeine was present in a few samples. Saliva/serum concentration ratios of dihydrocodeine were strongly dependent on the pH value of saliva and, to a lesser extent, on serum-protein binding. The salival serum ratios were more similar after chronic administration. Thedata suggest a passive diffusion process as the underlying mechanism for the transport of dihydrocodeine into saliva. After both single and chronic use, the presence of the drug in saliva can be used as evidence of recent substance administration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/05/20 alle ore 12:50:47