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Titolo:
Vitamin B-12-deficiency affects immunoglobulin production and cytokine levels in mice
Autore:
Funada, U; Wada, M; Kawata, T; Mori, K; Tamai, H; Isshiki, T; Onoda, J; Tanaka, N; Tadokoro, T; Maekawa, A;
Indirizzi:
Okayama Univ, Fac Educ, Okayama 7000082, Japan Okayama Univ Okayama Japan 7000082 niv, Fac Educ, Okayama 7000082, Japan Tokyo Univ Agr, Fac Appl Biosci, Setagaya Ku, Tokyo 1568502, Japan Tokyo Univ Agr Tokyo Japan 1568502 ci, Setagaya Ku, Tokyo 1568502, Japan Selfuso Hosp, Horinouchi, Saitama 3520023, Japan Selfuso Hosp Horinouchi Saitama Japan 3520023 chi, Saitama 3520023, Japan
Titolo Testata:
INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH
fascicolo: 1, volume: 71, anno: 2001,
pagine: 60 - 65
SICI:
0300-9831(200101)71:1<60:VBAIPA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERNICIOUS-ANEMIA; LYMPHOCYTE SUBPOPULATIONS; MEGALOBLASTIC-ANEMIA; FLOW-CYTOMETRY; RATS; RESTORATION; PROTEIN; SUBSETS; THERAPY; PATIENT;
Keywords:
CD4; CD8; IgE; IgG; interferon-gamma; interleukin-4; B-12-deficient mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Kawata, T Okayama Univ, Fac Educ, 2-5-1 Shikata Cho, Okayama 7008530, Japan Okayama Univ 2-5-1 Shikata Cho Okayama Japan 7008530 530, Japan
Citazione:
U. Funada et al., "Vitamin B-12-deficiency affects immunoglobulin production and cytokine levels in mice", INT J VIT N, 71(1), 2001, pp. 60-65

Abstract

To clarify the role of B-12 in the immunological function, serum C3, IgM, IgG, IgE contents, splenocytes expression of CD4, CD8, and CD4 positive intracellular IFN-gamma and IL-4 were examined in B-12-deficient mice, and theeffect of the administration of CH3-B-12 was also studied. Serum C3, IgM and IgG contents were lower in B-12-deficient mice than in the control mice. On the other hand, serum IgE content was sinificantly higher in B-12-deficient mice, and the value in CH3-B-12 administered mice, administered CH3-B-12 to B-12-deficient mice for 48 h before the end of feeding period, showeda tendency to recovery. CD4(+)CD8(-) cells and CD4(+)CD8(-)/CD4(-)CD8(+) ratio in splenocytes were significantly higher in B-12-deficient mice than in control mice. CD4(+)IFN-gamma (+) cells was significantly lower in B-12-deficient mice than in control mice, and CD4(+)IL-4(+) was significantly higher in B-12-deficient mice than in control mice. These results suggest thatB-12-deficiency causes CD4(+)CD8(-)T cells shift from the T helper type 1 to the T helper type 2, which participate in the IgE production and elevates CD4(+)CD8(-)/CD4(-)CD8(+) ratio. Thus, B-12 plays a role in maintaining the immune function in mice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 13:25:58