Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Interactive effect of hesperidin and vitamin E supplements on cholesterol metabolism in high cholesterol-fed rats
Autore:
Park, YB; Do, KM; Bok, SH; Lee, MK; Jeong, TS; Choi, MS;
Indirizzi:
Kyungpook Natl Univ, Dept Nutr & Food Sci, Puk Ku, Taegu 702701, South Korea Kyungpook Natl Univ Taegu South Korea 702701 , Taegu 702701, South Korea Kyungpook Natl Univ, Dept Genet Engn, Puk Ku, Taegu 702701, South Korea Kyungpook Natl Univ Taegu South Korea 702701 , Taegu 702701, South Korea KIST, Korea Inst Biosci & Biotechnol, Taejon 305606, South Korea KIST Taejon South Korea 305606 & Biotechnol, Taejon 305606, South Korea
Titolo Testata:
INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH
fascicolo: 1, volume: 71, anno: 2001,
pagine: 36 - 44
SICI:
0300-9831(200101)71:1<36:IEOHAV>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPEROXIDE-DISMUTASE; ACYL-COENZYME; REDUCTASE; LIVER; PLASMA; ATHEROSCLEROSIS; ACYLTRANSFERASE; INHIBITION; PEROXIDASE; ASSAY;
Keywords:
hesperidin; vitamin E; HMG-CoA reductase; ACAT; fecal sterols; cholesterol metabolism; antioxidant enzymes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Choi, MS Kyungpook Natl Univ, Dept Nutr & Food Sci, Puk Ku, 1370 Sank Yuk,Taegu 702701, South Korea Kyungpook Natl Univ 1370 Sank Yuk Taegu South Korea 702701 Korea
Citazione:
Y.B. Park et al., "Interactive effect of hesperidin and vitamin E supplements on cholesterol metabolism in high cholesterol-fed rats", INT J VIT N, 71(1), 2001, pp. 36-44

Abstract

Certain bioflavonoids are potent antioxidants and have pharmacologic effects similar to those of vitamin E. Accordingly, the interactive effect of hesperidin and vitamin E was studied with respect to cholesterol metabolism and the antioxidant status. Hesperidin supplement (0.1%. wt/wt) with comparable levels of vitamin E was provided with a high-cholesterol (1%, wt/wt) diet to rats fur 5 weeks. The amount of vitamin E included in the:hesperidin-free and hesperidin diets was either a low (low-E) or a normal (normal-E) level. The : hesperidin supplement and different levels of dietary vitamin Edid not significantly alter the concentrations of plasma triglycerides. However, the inclusion of hesperidin significantly lowered the concentration of plasma cholesterol in both the low-vitamin E group and the normal-vitamin E group compared to the hesperidin-free groups (p < 0.05). The hepatic triglyceride content was significantly lowered by the hesperidin supplement, as opposed to the plasma triglyceride content, regardless of the vitamin E level in the diet. The hepatic HMG-CoA reductase activity was significantlylowered by the hesperidin supplement with both the low-vitamin E and the normal-vitamin E compared to the hesperidin-free groups (p < 0.05). The hepatic HMG-CoA reductase activity was also significantly lowered with an increase in the dietary vitamin E within the hesperidin and hesperidin-free groups. The excretion of fecal neutral sterol and acidic sterols tended to be lower with the hesperidin supplement. Neither dietary hesperidin nor vitaminE significantly changed the hepatic antioxidant enzyme activity. This data indicates that hesperidin lowers the concentration of plasma cholesterol and the hepatic triglyceride content regardless of the dietary vitamin E level. However, the concentration of plasma cholesterol in the hesperidin-free groups was dependent on the dietary vitamin E level. This information may contribute to understanding the interactive effect of hesperidin and vitamin E on cholesterol biosynthesis in high cholesterol-fed rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 05:03:07