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Titolo:
Correlation between eosinophilia induced by CD4(+) T cells and bronchial hyper-responsiveness
Autore:
Nakata, A; Kaminuma, O; Ogawa, K; Fujimura, H; Fushimi, K; Kikkawa, H; Naito, K; Ikezawa, K; Egan, RW; Mori, A;
Indirizzi:
Tanabe Seiyaku Co Ltd, Discovery Res Lab, Toda, Saitama 3358505, Japan Tanabe Seiyaku Co Ltd Toda Saitama Japan 3358505 , Saitama 3358505, Japan Schering Plough Corp, Res Inst, Dept Allergy & Immunol, Kenilworth, NJ 07033 USA Schering Plough Corp Kenilworth NJ USA 07033 ol, Kenilworth, NJ 07033 USA Natl Sagamihara Hosp, Clin Res Lab Allergy & Rheumatol, Kanagawa 2288522, Japan Natl Sagamihara Hosp Kanagawa Japan 2288522 tol, Kanagawa 2288522, Japan
Titolo Testata:
INTERNATIONAL IMMUNOLOGY
fascicolo: 3, volume: 13, anno: 2001,
pagine: 329 - 339
SICI:
0953-8178(200103)13:3<329:CBEIBC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED AIRWAY INFLAMMATION; MAJOR BASIC-PROTEIN; INTERFERON-GAMMA; MURINE MODEL; MONOCLONAL-ANTIBODY; CYCLOSPORINE-A; MOUSE TRACHEA; LUNG DAMAGE; MAST-CELLS; B-CELLS;
Keywords:
cytokines; eosinophils; in vivo animal models; lung; T lymphocytes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Nakata, A Tanabe Seiyaku Co Ltd, Discovery Res Lab, 2-2-50 Kawagishi, Toda, Saitama 3358505, Japan Tanabe Seiyaku Co Ltd 2-2-50 Kawagishi Toda Saitama Japan 3358505
Citazione:
A. Nakata et al., "Correlation between eosinophilia induced by CD4(+) T cells and bronchial hyper-responsiveness", INT IMMUNOL, 13(3), 2001, pp. 329-339

Abstract

The relationship between CD4(+) T cell-mediated airway eosinophilic inflammation and bronchial hyper-responsiveness (BHR) was investigated. Ovalbumin-reactive T(h)o clones were adoptively transferred to unprimed BALB/c mice and then the mice were challenged by inhalation of the relevant antigen, Upon antigen provocation, infused Th clones infiltrated into the airways, followed by the accumulation and degranulation of eosinophils, goblet cell hyperplasia, edema and increase in bronchial responsiveness to acetylcholine. Transfer of several clones that differed in the levels of IL-5 production revealed that the magnitude of in vivo eosinophilia strongly correlated withthe IL-5-producing capacity of the infused T-h clones. Administration of anti-IL-5 mAb almost completely suppressed antigen-induced eosinophilic inflammation and BHR, Administration of anti-IL-4 mAb or anti-IFN-gamma mAb enhanced the eosinophilia and BHR, whereas anti-IL-2 mAb did not affect them, The number of accumulated eosinophils significantly correlated with the intensity of BHR, Our present results clearly demonstrated that CD4(+) T cellsinduced BHR as a result of eosinophilic inflammation: IL-5 totally regulated both responses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 07:04:55