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Titolo:
Is amisulpride an 'atypical' atypical antipsychotic agent?
Autore:
Lecrubier, Y;
Indirizzi:
Hop La Pitie Salpetriere, INSERM, U302, F-75013 Paris, France Hop La PitieSalpetriere Paris France F-75013 302, F-75013 Paris, France
Titolo Testata:
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
, volume: 15, anno: 2000, supplemento:, 4
pagine: S21 - S26
SICI:
0268-1315(200012)15:<S21:IAA'AA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEGATIVE SYMPTOMS; CHRONIC-SCHIZOPHRENIA; ACUTE EXACERBATIONS; DOPAMINE-RECEPTORS; CLOZAPINE; NEUROLEPTICS; IMPROVEMENT; HYPOFRONTALITY; HALOPERIDOL; ANTAGONIST;
Keywords:
dopaminergic receptors; positive symptoms; limbic system; negative symptoms; extrapyramidal symptoms; amisulpride; tolerability;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Lecrubier, Y Hop La Pitie Salpetriere, INSERM, U302, 47 Bd Hop, F-75013 Paris, France Hop La Pitie Salpetriere 47 Bd Hop Paris France F-75013 ance
Citazione:
Y. Lecrubier, "Is amisulpride an 'atypical' atypical antipsychotic agent?", INT CLIN PS, 15, 2000, pp. S21-S26

Abstract

Amisulpride is a novel antipsychotic with a pharmacological and clinical profile that differs from that of other atypical agents. Amisulpride is highly selective for dopamine D-2/D-3 receptor subtypes located in the limbic region, which is highly predictive of potent antipsychotic activity with a low potential to cause extrapyramidal symptoms (EPS), At the same time, its selective activity at presynaptic D-2/D-3 receptors is responsible for enhancing dopamine transmission, which predicts efficacy in the treatment of the negative symptoms of schizophrenia. Amisulpride thus has a unique profile: efficacy in controlling the symptoms of schizophrenia, whether predominantly positive or negative, combined with a low incidence of EPS. This profile is seen during both acute and chronic treatment. Amisulpride is thereforeindeed an 'atypical atypical'-a flexible antipsychotic the use of which can be tailored to the changing needs of the patient. It is thus a suitable first-line choice for the treatment of schizophrenia. Int clin Psychopharmacol 2000, 15 (suppl 4):S21-S26 (C) 2000 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/01/20 alle ore 18:56:16