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Titolo:
Decreased CD57 lymphocyte subset in patients with chronic Lyme disease
Autore:
Stricker, RB; Winger, EE;
Indirizzi:
Calif Pacific Med Ctr, Dept Med, San Francisco, CA 94108 USA Calif PacificMed Ctr San Francisco CA USA 94108 Francisco, CA 94108 USA Immodiagnost Labs, San Leandro, CA USA Immodiagnost Labs San Leandro CA USA odiagnost Labs, San Leandro, CA USA
Titolo Testata:
IMMUNOLOGY LETTERS
fascicolo: 1, volume: 76, anno: 2001,
pagine: 43 - 48
SICI:
0165-2478(20010201)76:1<43:DCLSIP>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL SUBSET; BORRELIA-BURGDORFERI INFECTION; MULTIPLE-SCLEROSIS; ARTHRITIS; IMMUNOPATHOGENESIS; DIAGNOSIS; SEROLOGY; GAMMA; BLOOD;
Keywords:
Lyme disease; lymphocyte subsets; CD57; multiple sclerosis; borrelia; HIV;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Stricker, RB Calif Pacific Med Ctr, Dept Med, 450 Sutter St,Suite 1504, San Francisco, CA 94108 USA Calif Pacific Med Ctr 450 Sutter St,Suite 1504 San Francisco CA USA 94108
Citazione:
R.B. Stricker e E.E. Winger, "Decreased CD57 lymphocyte subset in patients with chronic Lyme disease", IMMUNOL LET, 76(1), 2001, pp. 43-48

Abstract

Bac Background: Chronic Lyme disease (LD) is a debilitating illness causedby tickborne infection with the spirochete Borrelia burgdorferi Although immunologic abnormalities appear to play a role in this disease, specific immunologic markers of chronic LD have not been identified. Methods: We evaluated 73 patients with chronic LD for lymphocyte subset abnormalities using flow cytometry. Of these, 53 patients had predominant musculoskeletal symptoms. while 20 patients had predominant neurologic symptoms. The estimated duration of infection ranged from 3 months to 15 years, and all patients hadpositive serologic tests for B. burgdorferi. Ten patients with acute: to (infection less than 1 month) and 22 patients with acquired immunodeficiencysyndrome (AIDS) served as disease controls. Results: All 31 chronic LD patients who were tested prior to antibiotic treatment had significantly decreased CD57 lymphocyte counts (mean, 30 +/- 16 cells per mul: normal. 60-360 cells per mul, P < 0.001). Nineteen of 37 patients (51%) who were tested after initiating antibiotic therapy had decreased CD57 levels (mean, 66 +/- 39 cells per <mu>l), and all five patients tested after completing antibiotic treatment had normal CD57 counts (mean, 173 +/- 98 cells per mul). In contrast all 10 patients with acute LD and 82% of AIDS patients had normal CD57 levels, and the difference between these groups and the pre-treatment patients with chronic LD was significant (P < 0.001). Patients with chronic LDand predominant neurologic symptoms had significantly lower mean CD57 levels than patients with predominant musculoskeletal symptoms (30 +/- 21 vs. 58 +/- 37 cells per <mu>l, P = 0.002). CD57 levels increased in chronic LD patients whose symptoms improved, while patients with refractory disease hadpersistently low CD57 counts. Conclusions: A decrease in the CD57 lymphocyte subset may be an important marker of chronic to. Changes in the CD57 subset may be useful to monitor the response to therapy in this disease. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 11:37:29