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Titolo:
Activation of frontal premotor areas during suprathreshold transcranial magnetic stimulation of the left primary sensorimotor cortex: A glucose metabolic PET study
Autore:
Siebner, HR; Peller, M; Bartenstein, P; Willoch, F; Rossmeier, C; Schwaiger, M; Conrad, B;
Indirizzi:
Univ Coll London, Inst Neurol, MRC, Human Movement & Balance Unit, London WC1N 3BG, England Univ Coll London London England WC1N 3BG Unit, London WC1N 3BG, England Tech Univ Munich, Dept Neurol, D-8000 Munich, Germany Tech Univ Munich Munich Germany D-8000 pt Neurol, D-8000 Munich, Germany Tech Univ Munich, Dept Nucl Med, D-8000 Munich, Germany Tech Univ Munich Munich Germany D-8000 Nucl Med, D-8000 Munich, Germany
Titolo Testata:
HUMAN BRAIN MAPPING
fascicolo: 3, volume: 12, anno: 2001,
pagine: 157 - 167
SICI:
1065-9471(200103)12:3<157:AOFPAD>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; POSITRON EMISSION TOMOGRAPHY; PRIMARY MOTOR CORTEX; ADJACENT CINGULATE CORTEX; FUNCTIONAL BRAIN IMAGES; SUPPLEMENTARY-MOTOR; CORTICOSPINAL PROJECTIONS; MACAQUE MONKEY; INTERHEMISPHERIC INHIBITION; TOPOGRAPHIC ORGANIZATION;
Keywords:
primary sensorimotor hand area; intracerebral connectivity; premotor cortex; repetitive transcranial magnetic stimulation; positron emission tomography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Siebner, HR Univ Coll London, Inst Neurol, MRC, Human Movement & Balance Unit, Queen Sq, London WC1N 3BG, England Univ Coll London Queen Sq London England WC1N 3BG BG, England
Citazione:
H.R. Siebner et al., "Activation of frontal premotor areas during suprathreshold transcranial magnetic stimulation of the left primary sensorimotor cortex: A glucose metabolic PET study", HUM BRAIN M, 12(3), 2001, pp. 157-167

Abstract

We employed cerebral (18)Fluoro-deoxyglucose positron emission tomography ([F-18]FDG-PET) to visualize neuronal activation of the frontal motor and premotor cortex during suprathreshold repetitive transcranial magnetic stimulation (rTMS) applied to the left primary sensorimotor hand area (SM1(HAND)). Twelve right-handed normal subjects underwent two [F-18]FDG-PET measurements at baseline without rTMS and during suprathreshold 2 Hz rTMS of the left SM1(HAND). In the rTMS condition, 1,800 magnetic stimuli at an intensityof 140% of motor-resting threshold were delivered immediately after intravenous injection of [F-18]FDG. Relative differences in the normalized regional cerebral metabolic rate for glucose (rCMRglc) between the rTMS conditionand baseline were determined using a voxel-by-voxel Student's t-test and avolume-of-interest analysis. Data analysis was a priori restricted to primary motor and premotor areas in the frontal cortex, namely the SM1, the supplementary motor area (SMA), the lateral premotor cortex (PMC), and the caudal anterior cingulate cortex (ACC) of either hemisphere. In addition to a relative increase in normalized rCMRglc in the stimulated SM1(HAND), suprathreshold rTMS was associated with well-localized increases in normalized rCMRglc in the caudal SMA and ACC on the medial wall of the frontal cortex and in the right precentral gyrus in the lateral PMC rostrally to the SM1. These data demonstrate that a selective activation of the SM1(HAND) is paralleled by an activation of a distinct set of remote premotor areas, suggesting a functional interaction between the primary motor and premotor cortex inhumans. Hum. Brain Mapping 12:157-167, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 06:59:27