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Titolo:
Collagen type I alpha I and vitamin D receptor gene polymorphisms and bonemass in primary biliary cirrhosis
Autore:
Pares, A; Guanabens, N; Alvarez, L; De Osaba, MJM; Oriola, J; Pons, F; Caballeria, L; Monegal, A; Salvador, G; Jo, J; Peris, P; Rivera, F; Ballesta, AM; Rodes, J;
Indirizzi:
Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi & Sunyer, Liver Unit, E-08036 Barcelona, Spain Univ Barcelona Barcelona Spain E-08036 er Unit, E-08036 Barcelona, Spain Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi & Sunyer, Metab Bone Dis Unit, E-08036 Barcelona, Spain Univ Barcelona Barcelona Spain E-08036 is Unit, E-08036 Barcelona, Spain Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi & Sunyer, Dept Rheumatol, E-08036 Barcelona, Spain Univ Barcelona Barcelona Spain E-08036 eumatol, E-08036 Barcelona, Spain Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi & Sunyer, Dept Biochem, E-08036 Barcelona, Spain Univ Barcelona Barcelona Spain E-08036 Biochem, E-08036 Barcelona, Spain Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi & Sunyer, Dept Hormonol, E-08036 Barcelona, Spain Univ Barcelona Barcelona Spain E-08036 ormonol, E-08036 Barcelona, Spain Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi & Sunyer, Dept Nucl Med, E-08036 Barcelona, Spain Univ Barcelona Barcelona Spain E-08036 ucl Med, E-08036 Barcelona, Spain
Titolo Testata:
HEPATOLOGY
fascicolo: 3, volume: 33, anno: 2001,
pagine: 554 - 560
SICI:
0270-9139(200103)33:3<554:CTIAIA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
SP1 BINDING-SITE; MINERAL DENSITY; 25-HYDROXYVITAMIN-D3 TREATMENT; OSTEOPOROTIC FRACTURES; POSTMENOPAUSAL WOMEN; PREMENOPAUSAL WOMEN; DISEASE; TURNOVER; ALLELES; OSTEOMALACIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Pares, A Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi & Sunyer,Liver Unit, E-08036 Barcelona, Spain Univ Barcelona Barcelona Spain E-08036 E-08036 Barcelona, Spain
Citazione:
A. Pares et al., "Collagen type I alpha I and vitamin D receptor gene polymorphisms and bonemass in primary biliary cirrhosis", HEPATOLOGY, 33(3), 2001, pp. 554-560

Abstract

The potential influence of two gene polymorphisms, vitamin D receptor gene(VDR) and the gene encoding collagen type I alpha1 (COLIA1) Spl polymorphisms, in the reduced bone mass observed in patients with primary biliary cirrhosis (PBC) was assessed in 61 women with PBC (age, 54.1 +/- 1.1 years) byrestriction enzyme digestion of polymerase chain reaction (PCR)-amplified DNA extracted from whole blood. Bone mineral density (BMD) of the lumbar spine (L2-L4) and proximal femur were measured by X-ray absorptiometry. The severity of liver disease and cholestasis was also evaluated, and changes inBMD were calculated after a mean period of 2.9 +/- 0.3 years in 41 patients. Sixteen patients (26%) had the BE, 20 the bb (33%), and 25 Bb (41%) VDR genotypes, There were no significant baseline BMD differences among the 3 VDR genotypes. Forty-one patients (68%) had the SS, 16 the Ss (27%), and 3 the ss (5%) COLIA1 genotypes. The baseline lumbar BMD was significantly lower in patients having the s allele than in the homozygote SS patients (Z-score, -0.76 +/- 0.24 vs. -0.10 +/-. 0.17, P = .02), The severity of cholestasis was not related to the VDR or COLIA1 1 polymorphisms. Lumbar bone loss was independent of VDR and COLIA1 genotypes, but it was associated with cholestasis. In conclusion, the COLIA1 but not VDR polymorphism is a genetic marker of peak bone mass in patients with PBC, although the severity of cholestasis is the main factor for osteoporosis since it is associated with the rate of bone loss.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 20:23:00