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Titolo:
Effects of contralateral acoustical stimulation on three measures of cochlear function in the guinea pig
Autore:
Popelar, J; Erre, JP; Syka, J; Aran, JM;
Indirizzi:
Acad Sci Czech Republ, Inst Expt Med, Prague 14220 4, Czech Republic Acad Sci Czech Republ Prague Czech Republic 14220 4 20 4, Czech Republic Univ Bordeaux 2, Hop Pellegrin, INSERM, Equipe Mixte 99 27, F-33076 Bordeaux, France Univ Bordeaux 2 Bordeaux France F-33076 99 27, F-33076 Bordeaux, France
Titolo Testata:
HEARING RESEARCH
fascicolo: 1-2, volume: 152, anno: 2001,
pagine: 128 - 138
SICI:
0378-5955(200102)152:1-2<128:EOCASO>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
EVOKED OTOACOUSTIC EMISSIONS; AUDITORY-NERVE FIBERS; EFFERENT OLIVOCOCHLEAR NEURONS; OUTER HAIR-CELLS; ELECTRICAL-STIMULATION; ROUND-WINDOW; SOUND STIMULATION; UNIT RESPONSE; SUPPRESSION; GENTAMICIN;
Keywords:
transient otoacoustic emissions; auditory nerve; compound action potential; ensemble background activity; contralateral suppression; guinea pig;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Popelar, J Acad Sci Czech Republ, Inst Expt Med, Videnska 1083, Prague 14220 4, CzechRepublic Acad Sci Czech Republ Videnska 1083 Prague Czech Republic 14220 4
Citazione:
J. Popelar et al., "Effects of contralateral acoustical stimulation on three measures of cochlear function in the guinea pig", HEARING RES, 152(1-2), 2001, pp. 128-138

Abstract

The magnitudes of suppression of the click-evoked compound action potential of the auditory nerve (CAP), transient click-evoked otoacoustic emissions(TEOAEs) and ensemble background activity of the auditory nerve (EBA), elicited by contralateral acoustical stimulation, were compared in awake or lightly sedated guinea pigs. The contralateral ear was stimulated either by continuous broad-band noise or by low-pass or high-pass noise (intensity 41-62 dB SPL) with cut-off frequencies of 2, 8 and 12 kHz. The maximal suppression of TEOAEs was achieved by contralateral noise containing mainly low frequencies, whereas for suppression of the CAP it was necessary for middle frequencies to be present in the contralateral noise (less than 8 kHz). in contrast to this, EBA was suppressed mainly by high-frequency noise (higher than 8 kHz) whereas low- and middle-frequency noise was ineffective in suppressing EBA. Evaluation of the root mean square voltage of the EBA (filtered in frequency range 0.75-1.25 kHz) enabled the evaluation of fast and slowcomponents of olivocochlear activation. Both fast and dow effects were proportionally suppressed by individual types of contralateral stimulation. The mechanisms of TEOAEs and CAP generation has been confirmed in many earlier studies, but the origin of EBA has yet to be fully elucidated. The obtained data support the hypothesis that a large part of EBA is formed by spontaneous activity of high-frequency-tuned auditory nerve fibres. Suppression of the EBA magnitude during contralateral stimulation may be caused either by a reduced spontaneous firing rate or by a decrease in possible synchronised neuronal firing. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 12:03:11