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Titolo:
Regional distribution of calcium currents in frog semicircular canal hair cells
Autore:
Perin, P; Masetto, S; Martini, M; Rossi, ML; Rubbini, G; Rispoli, G; Guth, P; Zucca, G; Valli, P;
Indirizzi:
Univ Pavia, Sect Gen Physiol & Cell Biophys, Dept Cell & Mol Physiol & Pharmacol Sci, I-27100 Pavia, Italy Univ Pavia Pavia Italy I-27100 iol & Pharmacol Sci, I-27100 Pavia, Italy Univ Ferrara, Sect Physiol & Biophys, Dept Biol, INFM, I-44100 Ferrara, Italy Univ Ferrara Ferrara Italy I-44100 pt Biol, INFM, I-44100 Ferrara, Italy Tulane Univ, Dept Pharmacol, New Orleans, LA 70118 USA Tulane Univ New Orleans LA USA 70118 Pharmacol, New Orleans, LA 70118 USA
Titolo Testata:
HEARING RESEARCH
fascicolo: 1-2, volume: 152, anno: 2001,
pagine: 67 - 76
SICI:
0378-5955(200102)152:1-2<67:RDOCCI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CRISTA-AMPULLARIS; ELECTRICAL-PROPERTIES; POTASSIUM CURRENTS; CHANNELS; CHICK; LOCALIZATION; EXPRESSION; COCHLEA; RELEASE;
Keywords:
frog; vestibular; hair cell; semicircular canal; Ca current; patch-clamp; nimodipine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Perin, P Univ Pavia, Sect Gen Physiol & Cell Biophys, Dept Cell & Mol Physiol & Pharmacol Sci, Viale Forlanini 6, I-27100 Pavia, Italy Univ Pavia Viale Forlanini 6 Pavia Italy I-27100 00 Pavia, Italy
Citazione:
P. Perin et al., "Regional distribution of calcium currents in frog semicircular canal hair cells", HEARING RES, 152(1-2), 2001, pp. 67-76

Abstract

In the present work we studied the regional expression of voltage-dependent Ca channels in hair cells from the frog semicircular canals, employing whole-cell patch-clamp on isolated and in situ hair cells. Although Ca channels are thought to play a major role in afferent transmission, up to now no data were available regarding their distribution in vestibular organs. The problem appears of interest, especially in the light of recent results showing the presence of multiple Ca current components in semicircular canal hair cells. Our data suggest the presence, in all regions of the crista ampullaris, of two classes of cells, one displaying an inactivating Ca current (RI) and one lacking it. In the former cells, Ca current amplitude decreasedfrom the central to the peripheral zone (the maximal currents being observed in the intermediate zone). Only L-type and R2 current components displayed regional differences in expression, whereas the size and properties of R1, although variable among cells, were not regionalized. However, in cells lacking RI, Ca current amplitudes were similar regardless of cell shape andlocation. The possible contributions of this Ca current distribution to afferent discharge properties are discussed. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/06/20 alle ore 01:45:15