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Titolo:
Murine ileitis after intracellular parasite infection is controlled by TGF-beta-producing intraepithelial lymphocytes
Autore:
Buzoni-Gatel, D; Debbabi, H; Mennechet, FJD; Martin, V; Lepage, AC; Schwartzman, JD; Kasper, LH;
Indirizzi:
Dartmouth Med Sch, Dept Med & Microbiol, Hanover, NH USA Dartmouth Med Sch Hanover NH USA , Dept Med & Microbiol, Hanover, NH USA Dartmouth Med Sch, Dept Pathol, Hanover, NH USA Dartmouth Med Sch HanoverNH USA h Med Sch, Dept Pathol, Hanover, NH USA Fac Pharm Tours, Inst Natl Rech Agron, Lab Associe Immunol Parasitaire, Tours, France Fac Pharm Tours Tours France Associe Immunol Parasitaire, Tours, France CONICET, Inst Nacl Microbiol Dr Carlos G Malbran, Dept Parasitol, RA-1033 Buenos Aires, DF, Argentina CONICET Buenos Aires DF Argentina RA-1033 033 Buenos Aires, DF, Argentina
Titolo Testata:
GASTROENTEROLOGY
fascicolo: 4, volume: 120, anno: 2001,
pagine: 914 - 924
SICI:
0016-5085(200103)120:4<914:MIAIPI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-BETA; TOXOPLASMA-GONDII INFECTION; CD4(+) T-CELLS; IFN-GAMMA; INTERFERON-GAMMA; SMALL-INTESTINE; NITRIC-OXIDE; TNF-ALPHA; IN-VIVO; REGULATED EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Kasper, LH Dartmouth Med Sch, 640E Bordwell, Lebanon, NH 03756 USA Dartmouth Med Sch 640E Bordwell Lebanon NH USA 03756 03756 USA
Citazione:
D. Buzoni-Gatel et al., "Murine ileitis after intracellular parasite infection is controlled by TGF-beta-producing intraepithelial lymphocytes", GASTROENTY, 120(4), 2001, pp. 914-924

Abstract

Background & Aims:Acute inflammatory ileitis occurs in susceptible (C57BL/6) mice after oral infection with Toxoplasma gondii. Overproduction of interferon (IFN)-gamma and synthesis of nitric oxide mediate the inflammation. We evaluated the role of transforming growth factor (TGF)-beta produced by intraepithelial lymphocytes (IELs) in this process. Methods: We analyzed the histologic and immunologic consequences of adoptive transfer of antigen-primed IELs into susceptible mice treated with anti-TGF-beta before oral challenge with T. gondii cysts. An in vitro coculture of enterocytes and IELs assessed the production of chemokines and cytokines in the presence of anti-TGF-beta, Results: Antigen-primed IELs prevent acute ileitis in susceptible mice that is reversed with anti-TGF-beta. Resistant mice (CBA/J) develop ileitis after treatment with anti-TGF-beta. Antigen-primed IELs can induce systemic immunosuppression as measured by depressed IFN-gamma production. In vitro, primed IELs reduce the production of inflammatory chemokines by infected enterocytes and IFN-gamma by splenocytes, Conclusions: Regulation ofthe ileal inflammatory process resulting from T, gondii is dependent on TGF-beta -producing IELs, The IELs ape an essential component in gut homeostasis after oral infection with this parasite.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 11:15:07