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Titolo:
Apoptotic and necrotic brain lesions in a fatal case of carbon monoxide poisoning
Autore:
Uemura, K; Harada, K; Sadamitsu, D; Tsuruta, R; Takahashi, M; Aki, T; Yasuhara, M; Maekawa, T; Yoshida, K;
Indirizzi:
Yamaguchi Univ, Sch Med, Dept Legal Med, Ube, Yamaguchi 7558505, Japan Yamaguchi Univ Ube Yamaguchi Japan 7558505 Ube, Yamaguchi 7558505, Japan Univ Tokyo, Grad Sch Med, Dept Forens Med, Bunkyo Ku, Tokyo 1130033, JapanUniv Tokyo Tokyo Japan 1130033 rens Med, Bunkyo Ku, Tokyo 1130033, Japan Yamaguchi Univ, Sch Med, Dept Emergency & Crit Care Med, Ube, Yamaguchi 7558505, Japan Yamaguchi Univ Ube Yamaguchi Japan 7558505 Ube, Yamaguchi 7558505, Japan Yamaguchi Univ, Sch Med, Dept Surg Pathol, Ube, Yamaguchi 7558505, Japan Yamaguchi Univ Ube Yamaguchi Japan 7558505 Ube, Yamaguchi 7558505, Japan Kyoto Prefectural Univ Med, Dept Legal Med, Kyoto 6020841, Japan Kyoto Prefectural Univ Med Kyoto Japan 6020841 Med, Kyoto 6020841, Japan
Titolo Testata:
FORENSIC SCIENCE INTERNATIONAL
fascicolo: 2-3, volume: 116, anno: 2001,
pagine: 213 - 219
SICI:
0379-0738(20010215)116:2-3<213:AANBLI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-DEATH; FOREBRAIN ISCHEMIA; DNA FRAGMENTATION; NEURONAL DAMAGE; RAT-BRAIN; HYPOXIA;
Keywords:
apoptosis; necrosis; carbon monoxide intoxication; TdT-mediated dUTP-biotin nick-end labeling; DNA agarose gel electrophoresis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Uemura, K Yamaguchi Univ, Sch Med, Dept Legal Med, Ube, Yamaguchi 7558505,Japan Yamaguchi Univ Ube Yamaguchi Japan 7558505 guchi 7558505, Japan
Citazione:
K. Uemura et al., "Apoptotic and necrotic brain lesions in a fatal case of carbon monoxide poisoning", FOREN SCI I, 116(2-3), 2001, pp. 213-219

Abstract

A 41-year-old man was accidentally exposed to carbon monoxide (CO) gas andfound in a state of cardiopulmonary arrest while he took bath. After admission, he was resuscitated and underwent artificial ventilation in a comatose state and died about 19 h later Computed tomography (CT) examination disclosed bilateral low density area in the basal ganglia and the thalamus, a well-known finding in the CO intoxication. Necropsy, histological examination, DNA ladder assay gave the first line of evidence for the presence of apoptosis as well as necrosis in the human case of CO intoxication. TdT-mediated dUTP-biotin nick-end labeling (TUNEL) positive apoptotic cells were morepredominant in the CA2 area than in CAI area. There is general co-relationbetween the ratio of TUNEL-positive cells and the DNA laddering on the agarose gel. Basal ganglia and thalamus, which showed bilateral low density area in CT, were revealed to be severe edema. The two types of cell death occurred in the cortex, basal ganglia, hippocampus, thalamus, and cerebellum. Hypoxia caused by GO-hemoglobin formation alone cannot explain the phenomena. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 17:40:39