Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Cytomegalovirus infection increases the expression and activity of ecto-ATPase (CD39) and ecto-5 ' nucleotidase (CD73) on endothelial cells
Autore:
Kas-Deelen, AM; Bakker, WW; Olinga, P; Visser, J; de Maar, EF; van Son, WJ; The, TH; Harmsen, MC;
Indirizzi:
Univ Groningen Hosp, Dept Clin Immunol, NL-9713 GZ Groningen, Netherlands Univ Groningen Hosp Groningen Netherlands NL-9713 GZ ningen, Netherlands Univ Groningen Hosp, Dept Pathol, NL-9713 GZ Groningen, Netherlands Univ Groningen Hosp Groningen Netherlands NL-9713 GZ ningen, Netherlands Univ Groningen Hosp, Dept Nephrol, NL-9713 GZ Groningen, Netherlands Univ Groningen Hosp Groningen Netherlands NL-9713 GZ ningen, Netherlands GUIDE, Dept Pharmacokinet & Drug Delivery, Groningen, Netherlands GUIDE Groningen Netherlands net & Drug Delivery, Groningen, Netherlands GUIDE, Dept Med Biol, Groningen, Netherlands GUIDE Groningen Netherlands UIDE, Dept Med Biol, Groningen, Netherlands
Titolo Testata:
FEBS LETTERS
fascicolo: 1-2, volume: 491, anno: 2001,
pagine: 21 - 25
SICI:
0014-5793(20010223)491:1-2<21:CIITEA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLATELET-AGGREGATION; PLASMA FACTOR; ADENOSINE; RAT; ACTIVATION; ECTO-5'-NUCLEOTIDASE; MACROPHAGES; IMPAIRMENT; INHIBITION; CULTURE;
Keywords:
cytomegalovirus; endothelium; ecto-ATPase; CD39; ecto-5 ' nucleotidase; CD73;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Harmsen, MC Univ Groningen Hosp, Dept Clin Immunol, Hanzeplein 1, NL-9713 GZ Groningen, Netherlands Univ Groningen Hosp Hanzeplein 1 Groningen Netherlands NL-9713 GZ
Citazione:
A.M. Kas-Deelen et al., "Cytomegalovirus infection increases the expression and activity of ecto-ATPase (CD39) and ecto-5 ' nucleotidase (CD73) on endothelial cells", FEBS LETTER, 491(1-2), 2001, pp. 21-25

Abstract

We describe enhanced expression and enzymatic activity of ecto-ATPase and ecto-5' nucleotidase on CMV infected endothelial cells as compared to uninfected cells, These ectoenzymes play a major role in modulation of platelet activation and aggregation. Furthermore, adenosine has a modulatory effect upon inflammation. Addition of ATP, ADP or AMP to cultures of CMV infected or uninfected endothelial cells revealed increased turnover of AMP in CMV infected endothelial cells. in addition, the superoxide production by stimulated polymorphonuclear cells was inhibited in the presence of CMV infected endothelial cells as compared to uninfected cells, probably due to the enhanced activity of ecto-5'-nucleotidase and associated to production of adenosine. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 07:07:07