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Titolo:
CCK2 receptor antagonists
Autore:
McDonald, IM;
Indirizzi:
James Black Fdn, London SE24 9JE, England James Black Fdn London EnglandSE24 9JE ck Fdn, London SE24 9JE, England
Titolo Testata:
EXPERT OPINION ON THERAPEUTIC PATENTS
fascicolo: 3, volume: 11, anno: 2001,
pagine: 445 - 462
SICI:
1354-3776(200103)11:3<445:CRA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHOLECYSTOKININ-B RECEPTOR; ANTIGASTRIN ACTIVITY RELATIONSHIPS; IN-VIVO; ACID-DERIVATIVES; PANIC DISORDER; HIGH-AFFINITY; PHARMACOLOGICAL PROPERTIES; BIOLOGICAL-ACTIVITY; RAT STOMACH; POTENT;
Keywords:
acid secretion; anxiety; CCK2; CCK2 receptor antagonist; cholecystokinin; gastrin; panic disorder;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
72
Recensione:
Indirizzi per estratti:
Indirizzo: McDonald, IM James Black Fdn, 68 Half Moon Lane, London SE24 9JE, England James Black Fdn 68 Half Moon Lane London England SE24 9JE nd
Citazione:
I.M. McDonald, "CCK2 receptor antagonists", EXPERT OP T, 11(3), 2001, pp. 445-462

Abstract

Recognition that the gastrointestinal polypeptide hormone gastrin affects diverse actions. such as gastric acid secretion and gastrointestinal cell growth in peripheral tissues, has prompted efforts to obtain agents that inhibit its action. This has mainly been approached through the use of CCK2 receptor antagonists which also have the potential to inhibit cholecystokinin-mediated CNS effects, such as anxiety and pain. However. results obtained so far from compounds of this type in the clinic have been disappointing due to their low oral bioavailability. This has resulted from physicochemicallimitations of the compounds examined, such as solubility, and attempts tofurther optimise these initial candidates have also spawned CCK2 receptor antagonists based on other structural types. These new compounds may ultimately demonstrate therapeutic utility for CCK2 receptor antagonists.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 07:29:20