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Titolo:
Effect of pre-loading oral glucosamine HCI/chondroitin sulfate/manganese ascorbate combination on experimental arthritis in rats
Autore:
Beren, J; Hill, SL; Diener-West, M; Rose, NR;
Indirizzi:
Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA Johns HopkinsMed Inst Baltimore MD USA 21205 ol, Baltimore, MD 21205 USA Johns Hopkins Med Inst, W Harry Feinstone Dept Mol Microbiol & Immunol, Baltimore, MD 21205 USA Johns Hopkins Med Inst Baltimore MD USA 21205 ol, Baltimore, MD 21205 USA Johns Hopkins Med Inst, Dept Biostat, Baltimore, MD 21205 USA Johns Hopkins Med Inst Baltimore MD USA 21205 at, Baltimore, MD 21205 USA
Titolo Testata:
EXPERIMENTAL BIOLOGY AND MEDICINE
fascicolo: 2, volume: 226, anno: 2001,
pagine: 144 - 151
SICI:
1535-3702(200102)226:2<144:EOPOGH>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEGENERATIVE JOINT DISEASE; CHONDROITIN SULFATE; MANGANESE ASCORBATE; KNEE OSTEOARTHRITIS; OSTEO-ARTHRITIS; DOUBLE-BLIND; COLLAGEN; CARTILAGE; EFFICACY; HORSES;
Keywords:
glucosamine hydrochloride; sodium chondroitin sulfate; arthritis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Rose, NR Johns Hopkins Univ, Sch Med, Dept Pathol, 659 Ross Res Bldg,720 Rutland Ave, Baltimore, MD 21205 USA Johns Hopkins Univ 659 Ross Res Bldg,720 Rutland Ave Baltimore MD USA 21205
Citazione:
J. Beren et al., "Effect of pre-loading oral glucosamine HCI/chondroitin sulfate/manganese ascorbate combination on experimental arthritis in rats", EXP BIOL ME, 226(2), 2001, pp. 144-151

Abstract

The therapeutic effect of a nutritional supplement consisting of a combination of glucosamine hydrochloride (FCHG49), purified sodium chondroitin sulfate (TRH122), and manganese ascorbate (GCM)(3) was investigated in the ratmodel of collagen-induced autoimmune arthritis (CIA). The GCM compound wasmixed with a palatable nutritional paste (Nutri-cal(R) [NC]). Oral administration of the NC/GCM compound was initiated in 26 rats 10 days before immunization and continued until the day of sacrifice. One group of 12 control rats was given no oral agents; a second group of 12 control rats received NC only. Evaluations included arthritis index (AI) scoring by three independent evaluators, histologic index (Hr) scoring of lesions, T-cell proliferation, and serological studies for antibody classes and sub-classes, Both theAl and HI criteria showed a statistically significant reduction in the prevalence of CIA in rats pretreated with the NC/GCM (54%) compared to the combined control groups (96%, chi (2) analysis P = 0.001), Rats fed the NC/GCMalso exhibited a significant decrease in the severity of autoimmune arthritis in both the Al and HI compared to control Group 2 (immunized-NC) (chi (2) analysis P < 0.05), Histological studies verified the decreased incidence of arthritis in the NC/GCM group compared to control Group 2. GCM treatment failed to alter T-cell proliferation and antibody productionto bovine type-if collagen, indicating that its effects are not due to alteration of the antigen-specific immune response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 13:49:22