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Titolo:
Biological effects of long-term caloric restriction: Adaptation with simultaneous administration of caloric stress plus repeated immobilization stress in rats
Autore:
Gursoy, G; Cardounel, A; Hu, Y; Kalimi, M;
Indirizzi:
Virginia Commonwealth Univ, Med Coll Virginia, Dept Physiol, Richmond, VA 23298 USA Virginia Commonwealth Univ Richmond VA USA 23298 , Richmond, VA 23298 USA
Titolo Testata:
EXPERIMENTAL BIOLOGY AND MEDICINE
fascicolo: 2, volume: 226, anno: 2001,
pagine: 97 - 102
SICI:
1535-3702(200102)226:2<97:BEOLCR>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIETARY RESTRICTION; LIPID-PEROXIDATION; FOOD RESTRICTION; RHESUS-MONKEYS; AGE; EXPRESSION; PROTEINS; LIVER; GLUCOCORTICOIDS; APOPTOSIS;
Keywords:
caloric restriction; immobilization stress; corticosterone levels; glucocorticoid receptor; lipid peroxidation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Kalimi, M Virginia Commonwealth Univ, Med Coll Virginia, Dept Physiol, Box551, Richmond, VA 23298 USA Virginia Commonwealth Univ Box 551 Richmond VAUSA 23298 298 USA
Citazione:
G. Gursoy et al., "Biological effects of long-term caloric restriction: Adaptation with simultaneous administration of caloric stress plus repeated immobilization stress in rats", EXP BIOL ME, 226(2), 2001, pp. 97-102

Abstract

In the present study, we have established the biological effects during 8 weeks of (i) caloric restriction (Cal) and (ii) simultaneous administrationof Cal plus 2 hr daily immobilization stress using male Sprague-Dawley rats, Animals were divided into three equal groups: (i) ad libitum fed, (ii) 30% restriction of food intake of the ad libitum diet, and (iii) 30% restriction of food intake plus 2 hr daily immobilization stress. Caloric-restricted animals gained only 30% of the total body weight of the unrestricted animals but received 70% of the food of those rats. Cal animals showed a significant loss in their relative liver and thymus weight and a significant gain in their relative adrenal and testis weight as compared to the control animals. Cal animals had almost P-fold higher levels of plasma corticosteronelevels with a dramatic decrease in the total glucocorticoid receptor (GR) levels in the liver, thymus, heart, and testis as compared to ad libitum fed control animals. Interestingly, Cal animals showed higher levels of lipidperoxidation in both the liver and heart, indicating increased oxidative activities in these tissues when compared with the control animals. In addition, Cat animals had increased heat shock protein 70 (HSP 70) content in the testis. Surprisingly, hardly any significant differences were observed ineither total body weight gain, organ weights, plasma corticosterone levels, or lipid peroxidation between Cal animals and Cal plus immobilization-stressed animals. The results obtained suggest that (i) several stress-relatedresponses such as inhibition of total body weight gain, increased adrenal weight, decreased thymus weight, increased plasma corticosterone, and lipidperoxidation levels in the liver and heart are associated with Gal, but (ii) no additional effects were observed on the parameters that were measuredwhen two stress regimens were given simultaneously, suggesting that animals subjected to two stress regimens can protect themselves by controlling their stress-related thresholds of response through adaptation.

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Documento generato il 23/01/20 alle ore 06:25:18