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Titolo:
Hormonal and neurotransmitter roles for angiotensin in the regulation of central autonomic function
Autore:
Ferguson, AV; Washburn, DLS; Latchford, KJ;
Indirizzi:
Queens Univ, Dept Physiol, Kingston, ON K7L 3N6, Canada Queens Univ Kingston ON Canada K7L 3N6 siol, Kingston, ON K7L 3N6, Canada
Titolo Testata:
EXPERIMENTAL BIOLOGY AND MEDICINE
fascicolo: 2, volume: 226, anno: 2001,
pagine: 85 - 96
SICI:
1535-3702(200102)226:2<85:HANRFA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBFORNICAL ORGAN NEURONS; II RECEPTOR SUBTYPES; SPONTANEOUSLY HYPERTENSIVE RATS; INDUCED VASOPRESSIN RELEASE; ATRIAL-NATRIURETIC-FACTOR; ACTIVATED PROTEIN-KINASE; CENTRAL-NERVOUS-SYSTEM; TRANSIENT K+ CURRENT; PARAVENTRICULAR NUCLEUS; SUPRAOPTIC NEURONS;
Keywords:
angiotensin; neurotransmitter; central autonomic control; subfornical organ; paraventricular nucleus;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
128
Recensione:
Indirizzi per estratti:
Indirizzo: Ferguson, AV Queens Univ, Dept Physiol, Kingston, ON K7L 3N6, Canada Queens Univ Kingston ON Canada K7L 3N6 n, ON K7L 3N6, Canada
Citazione:
A.V. Ferguson et al., "Hormonal and neurotransmitter roles for angiotensin in the regulation of central autonomic function", EXP BIOL ME, 226(2), 2001, pp. 85-96

Abstract

In this review we present the case for both hormonal and neurotransmitter actions of angiotensin II (ANG) in the control of neuronal excitability in a simple neural pathway involved in central autonomic regulation. We will present both single-cell and whole-animal data highlighting hormonal roles for ANG in controlling the excitability of subfornical organ (SFO) neurons. More controversially we will also present the case for a neurotransmitter role for ANG in SFO neurons in controlling the excitability of identified neurons in the paraventricular nucleus (PVN) of the hypothalamus. In this review we highlight the similarities between the actions of ANG on these two populations of neurons in an attempt to emphasize that whether we call such actions "hormonal" or "neurotransmitter" is largely semantic. In fact such definitions only refer to the method of delivery of the chemical messenger,in this case ANG, to its cellular site of action, in this case the AT(1) receptor. We also described in this review some novel concepts that may underlie synthesis, metabolic processing, and co-transmitter actions of ANG in this pathway, We hope that such suggestions may lead ultimately to the development of broader guiding principles to enhance our understanding of the multiplicity of physiological uses for single chemical messengers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:09:28