Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effects of spinorphin and tynorphin on synaptic transmission in rat hippocampal slices
Autore:
Yamazaki, T; Honda, M; Yamamoto, Y; Hazato, T; Ono, H;
Indirizzi:
Sci Univ Tokyo, Fac Pharmaceut Sci, Dept Pharmacol, Shinjuku Ku, Tokyo 1620826, Japan Sci Univ Tokyo Tokyo Japan 1620826 ol, Shinjuku Ku, Tokyo 1620826, Japan Tokyo Metropolitan Inst Med Sci, Dept Canc Therapeut, Bunkyo Ku, Tokyo 1130021, Japan Tokyo Metropolitan Inst Med Sci Tokyo Japan 1130021 Tokyo 1130021, Japan
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 2-3, volume: 413, anno: 2001,
pagine: 173 - 178
SICI:
0014-2999(20010216)413:2-3<173:EOSATO>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; ENKEPHALIN-DEGRADING ENZYMES; PEPTIDASE INHIBITORS; ENDOGENOUS INHIBITOR; COMPLETE PROTECTION; HYDROLYSIS; AMASTATIN; CAPTOPRIL; PHOSPHORAMIDON; IDENTIFICATION;
Keywords:
spinorphin; tynorphin; enkephalin-degrading enzyme; hippocampus; field potential;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Ono, H Nagoya City Univ, Fac Pharmaceut Sci, Dept Pharmacol & Therapeut, Mizuho Ku, 3-1 Tanabe-dori, Nagoya, Aichi 4678603, Japan Nagoya City Univ 3-1 Tanabe-dori Nagoya Aichi Japan 4678603 , Japan
Citazione:
T. Yamazaki et al., "Effects of spinorphin and tynorphin on synaptic transmission in rat hippocampal slices", EUR J PHARM, 413(2-3), 2001, pp. 173-178

Abstract

Spinorphin has been isolated from the bovine spinal cord as an endogenous inhibitor of enkephalin-degrading enzymes (aminopeptidase, dipeptidyl aminopeptidase III, angiotensin-converting enzyme and enkephalinase), and tynorphin has been synthesized as a more potent inhibitor of dipeptidyl aminopeptidase III. In this study, the effects of spinorphin and tynorphin on synaptic transmission were studied in rat isolated hippocampal slices. Field potentials were recorded from the CA1 region after stimulation of Schaffer collaterals. Spinorphin (1 muM), which alone had no effect, potentiated the facilitatory effects of enkephalin on the filed potentials at a stimulation interval of 15 s. At a stimulation interval of 10-4 s, spinorphin alone frequency dependently inhibited the field potential. On the other hand, tynorphin (1 muM), which alone had no effect at any stimulus interval, tended to potentiate the facilitatory effects of enkephalin. Spinorphin blocked long-term potentiation induced by tetanic stimulation (100 Hz, 1 s), whereas tynorphin had no effect on long-term potentiation. These results suggest that, at a low stimulation frequency, spinorphin potentiates the facilitatory effects of enkephalin by preventing degradation of enkephalin, whereas at a high stimulation frequency spinorphin use dependently inhibits synaptic transmission independently of enkephalin. On the other hand, tynorphin tends to potentiate the facilitatory effects of enkephalin without use-dependent inhibition. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 13:44:31