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Titolo:
Negative interaction of dopamine D2 receptor antagonists and GBR 12909 andGBR 12935 dopamine uptake inhibitors in the nucleus accumbens
Autore:
Rahman, S; Engleman, E; Simon, J; McBride, WJ;
Indirizzi:
Indiana Univ, Sch Med, Dept Psychiat, Inst Psychiat Res, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 at Res, Indianapolis, IN 46202 USA
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1, volume: 414, anno: 2001,
pagine: 37 - 44
SICI:
0014-2999(20010223)414:1<37:NIODDR>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREELY MOVING RATS; VENTRAL TEGMENTAL AREA; EXTRACELLULAR DOPAMINE; INTRACEREBRAL DIALYSIS; STRIATAL SLICES; UPTAKE BLOCKERS; BRAIN DIALYSIS; RELEASE; MICRODIALYSIS; SEROTONIN;
Keywords:
nucleus accumbens; dopamine uptake; GBR 12909; GBR 12935; sulpiride; raclopride; microdialysis; in vivo;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: McBride, WJ Indiana Univ, Sch Med, Dept Psychiat, Inst Psychiat Res, 791 Union Dr, Indianapolis, IN 46202 USA Indiana Univ 791 Union Dr Indianapolis IN USA 46202 46202 USA
Citazione:
S. Rahman et al., "Negative interaction of dopamine D2 receptor antagonists and GBR 12909 andGBR 12935 dopamine uptake inhibitors in the nucleus accumbens", EUR J PHARM, 414(1), 2001, pp. 37-44

Abstract

The objective of this study was to examine the interaction of dopamine D2 receptor antagonists and dopamine uptake inhibitors on the regulation of extracellular dopamine release in the nucleus accumbens of Wistar rats employing in vivo microdialysis and in vitro dopamine uptake studies. Applicationof the D2 receptor antagonists raclopride (100 mum) or sulpiride (100 mum)alone through the microdialysis probe in the nucleus accumbens for 60 min increased the extracellular levels of dopamine in the nucleus accumbens to 150% and 200% of basal, respectively. Perfusion of the nucleus accumbens for 60 min with the dopamine uptake inhibitors, 1-[2-[bis(4-Fluorophenyl)methoxy]ethyl]-4-[3-phenylpropyl]piperazine dihydrochloride (GBR 12909; 100 mum) or 1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenylpropyl)-piperazine dihydrochloride (GBR 12935; 100 mum) alone, increased the extracellular levels of dopamine in the nucleus accumbens to 400% and 350% of basal, respectively. Go-perfusion of 100 muM GBR 12909 or GBR 12935 with either 100 muM sulpiride orraclopride produced a significant reduction in the GBR 12909 or GBR 12935 induced increase in the extracellular levels of dopamine to basal levels. In vitro, GBR 12909 (1-9 nM) dose-dependently inhibited active uptake of [H-3]dopamine in homogenates of the nucleus accumbens. Addition of 100 mum sulpiride had little effect on GBR 12909 inhibition of [H-3] dopamine uptake, suggesting that dopamine D2 receptor antagonists are not blocking the actions of the GBR-type dopamine uptake inhibitors at the dopamine transporter. Overall, the data suggest that complex interactions occur in vivo between D2 antagonists and GBR-type dopamine uptake inhibitors, which negate their effects on elevating the extracellular levels of dopamine in the nucleus accumbens. (C) 2001 Published by Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 16:34:03