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Titolo:
Rise and fall of asthma-related mortality in Italy and sales of beta 2-agonists, 1980-1994
Autore:
Romano, F; Recchia, G; Staniscia, T; Bonitatibus, A; Villa, M; Nicolosi, A; De Carli, G; Mannino, S;
Indirizzi:
Univ G Annunzio Chieti, Epidemiol Sect, Dept Biomed Sci, I-66013 Chieti, Italy Univ G Annunzio Chieti Chieti Italy I-66013 d Sci, I-66013 Chieti, Italy
Titolo Testata:
EUROPEAN JOURNAL OF EPIDEMIOLOGY
fascicolo: 9, volume: 16, anno: 2000,
pagine: 783 - 787
SICI:
0393-2990(2000)16:9<783:RAFOAM>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
INHALED BETA-AGONISTS; NEAR-FATAL ASTHMA; NEW-ZEALAND; PRESCRIBED FENOTEROL; DEATH; EPIDEMIC; FRANCE; TRENDS;
Keywords:
beta(2)-agonists; asthma; ecological studies; mortality; pharmacoepidemiology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Romano, F Univ G Annunzio Chieti, Epidemiol Sect, Dept Biomed Sci, Via Vestini, I-66013 Chieti, Italy Univ G Annunzio Chieti Via Vestini Chieti Italy I-66013 , Italy
Citazione:
F. Romano et al., "Rise and fall of asthma-related mortality in Italy and sales of beta 2-agonists, 1980-1994", EUR J EPID, 16(9), 2000, pp. 783-787

Abstract

We performed this study with the aims of describing the trend of asthma-related mortality in Italy between 1980 and 1994, and to evaluate the relationship between sale estimates of beta (2)-agonists drugs and mortality from asthma. For asthma mortality we used data provided by National Institute ofStatistics, for sale estimates of beta (2)-agonists we used data provided by IMS HEALTH. We calculated the gender specific age-standardized incidencerates of asthma-related deaths for all ages and for age classes. We found that estimates for asthma-related mortality steadily increased between 1980and 1987 in both sexes, and thereafter decreased. In people, aged between 34 and 64 and over 64, death rates in males were significantly higher than in females while the rates in those aged less than 34, were mostly similar in both gender. The overall exposure to beta (2)-agonists (alone and in combination) increased from 1980 to 1990, remained stable between 1990 and 1993, and increased steeply in 1994. We conclude that asthma-related death rates have declined since the mid-1980's. This decline has been more pronounced in males and in the older ages, while the rates in younger patients of both genders have remained nearly unchanged. Our data do not substantiate thehypothesis of an increased risk of asthma-related mortality associated to the use of inhaled beta (2)-agonists in general nor fenoterol or salbutamolin particular.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:38:17