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Titolo:
Immunohistochemical localization of somatostatin receptor type 2A in rat and human tissues
Autore:
Kimura, N; Schindler, M; Kasai, N; Kimura, I;
Indirizzi:
Tohoku Rosai Hosp, Dept Pathol & Lab Med, Aoba Ku, Sendai, Miyagi 9818563,Japan Tohoku Rosai Hosp Sendai Miyagi Japan 9818563 endai, Miyagi 9818563,Japan Tohoku Univ, Grad Sch Med Sci, Dept Pathol, Sendai, Miyagi 9808575, Japan Tohoku Univ Sendai Miyagi Japan 9808575 ol, Sendai, Miyagi 9808575, Japan Univ Cambridge, Glaxo Inst Appl Pharmacol, Dept Pharmacol, Cambridge CB2 10J, England Univ Cambridge Cambridge England CB2 10J col, Cambridge CB2 10J, England Tohoku Grad Sch Med, Inst Anim Experimentat, Sendai, Miyagi 9808575, JapanTohoku Grad Sch Med Sendai Miyagi Japan 9808575 ai, Miyagi 9808575, Japan Natl Yamagata Hosp, Dept Neurol, Yamagata 9900876, Japan Natl Yamagata Hosp Yamagata Japan 9900876 eurol, Yamagata 9900876, Japan
Titolo Testata:
ENDOCRINE JOURNAL
fascicolo: 1, volume: 48, anno: 2001,
pagine: 95 - 102
SICI:
0918-8959(200102)48:1<95:ILOSRT>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELECTRON-MICROSCOPIC AUTORADIOGRAPHY; GASTROINTESTINAL-TRACT; PITUITARY-TUMORS; MESSENGER-RNAS; ISLET CELLS; EXPRESSION; SUBTYPES; ANALOGS; SST2A; ANTIBODIES;
Keywords:
somatostatin receptor type 2A; immunohistochemistry; pancreas; gastrointestinal tract; adrenal gland;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Kimura, N Tohoku Rosai Hosp, Dept Pathol & Lab Med, Aoba Ku, 21-3-4 Dainohara, Sendai, Miyagi 9818563, Japan Tohoku Rosai Hosp 21-3-4 Dainohara Sendai Miyagi Japan 9818563 n
Citazione:
N. Kimura et al., "Immunohistochemical localization of somatostatin receptor type 2A in rat and human tissues", ENDOCR J, 48(1), 2001, pp. 95-102

Abstract

In this study, we elucidated the cellular localization of somatostatin receptor (SSTR) by immunohistochemistry using an antibody specific for SSTR type 2A (SSTR2A) in various organs of rat and human. SSTR2A expression was basically similar in rat and human, except in the pancreas and adrenal cortex. In the pituitary gland, the posterior lobe and the majority of growth hormone cells and some ACTH and TSH cells expressed SSTR2A. In rat adrenal gland, the zona glomerulosa strongly expressed SSTR2A, whereas zone-specific immunoreactivity was not observed in human. The adrenal medulla moderately expressed SSTR2A in both rat and human. SSTR2A immunoreactivity was observedin islet cells and some ductal cells in human pancreas, and also in acinarcells of rat pancreas. In gastrointestinal (GI) tract, the majority of crypt cells and nerve plexuses strongly expressed SSTR2A. The number of SSTR2Apositive cells was much more than that of chromogranin A positive endocrine cells. In the kidney, the glomerular capillaries and collecting tubules, but not proximal tubules, showed immunoreactivity. SSTR2A immunoreactivity was observed not only in endocrine cells but also in non-endocrine cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 14:40:50