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Titolo:
The therapeutic potential of regulated hypothermia
Autore:
Gordon, CJ;
Indirizzi:
US EPA, Div Neurotoxicol, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA US EPA Res Triangle Pk NC USA 27711 es Lab, Res Triangle Pk, NC 27711 USA
Titolo Testata:
EMERGENCY MEDICINE JOURNAL
fascicolo: 2, volume: 18, anno: 2001,
pagine: 81 - 89
SICI:
1472-0205(200103)18:2<81:TTPORH>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
BODY-CORE TEMPERATURE; BRAIN INJURY; THERMOREGULATORY RESPONSE; BEHAVIORAL THERMOREGULATION; ISCHEMIC BRAIN; MICE; RAT; HYPOXIA; MODEL; EXTRAPOLATION;
Keywords:
temperature regulation; chemical toxicants; ischaemia; stroke;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
75
Recensione:
Indirizzi per estratti:
Indirizzo: Gordon, CJ US EPA, Div Neurotoxicol, Natl Hlth & Environm Effects Res Lab,Res Triangle Pk, NC 27711 USA US EPA Res Triangle Pk NC USA 27711 Triangle Pk, NC 27711 USA
Citazione:
C.J. Gordon, "The therapeutic potential of regulated hypothermia", EMERG MED J, 18(2), 2001, pp. 81-89

Abstract

Reducing body temperature of rodents has been found to improve their survival to ischaemia, hypoxia, chemical toxicants, and many other types of insults. Larger species, including humans, may also benefit from a lower body temperature when recovering from CNS ischaemia and other traumatic insults. Rodents subjected to these insults undergo a regulated hypothermic response(that is, decrease in set point temperature) characterised by preference for cooler ambient temperatures, peripheral vasodilatation, and reduced metabolic rate. However, forced hypothermia (that is, body temperature forced below set point) is the only method used in the study and treatment of humanpathological insults. The therapeutic efficacy of the hypothermic treatment is likely to be influenced by the nature of the reduction in body temperature (that is, forced versus regulated). Homeostatic mechanisms counter forced reductions in body temperature resulting in physiological stress and decreased efficacy of the hypothermic treatment. On the other hand, regulatedhypothermia would seem to be the best means of achieving a therapeutic benefit because thermal homeostatic systems mediate a controlled reduction in core temperature.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:36:26