Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
A genome scan for type 2 diabetes susceptibility loci in a genetically isolated population
Autore:
Permutt, MA; Wasson, JC; Suarez, BK; Lin, J; Thomas, J; Meyer, J; Lewitzky, S; Rennich, JS; Parker, A; DuPrat, L; Maruti, S; Chayen, S; Glaser, B;
Indirizzi:
Washington Univ, Sch Med, Div Endocrinol Diabet & Metab, St Louis, MO USA Washington Univ St Louis MO USA ocrinol Diabet & Metab, St Louis, MO USA Washington Univ, Sch Med, Dept Psychiat, St Louis, MO USA Washington UnivSt Louis MO USA Sch Med, Dept Psychiat, St Louis, MO USA Warner Lambert Parke Davis, Parke Davis Pharmaceut Res, Ann Arbor, MI 48105 USA Warner Lambert Parke Davis Ann Arbor MI USA 48105 Ann Arbor, MI 48105 USA Millennium Pharmaceut, Cambridge, MA USA Millennium Pharmaceut Cambridge MA USA ium Pharmaceut, Cambridge, MA USA Hebrew Univ Jerusalem, Hadassah Med Ctr, Dept Endocrinol & Metab, Jerusalem, Israel Hebrew Univ Jerusalem Jerusalem Israel rinol & Metab, Jerusalem, Israel
Titolo Testata:
DIABETES
fascicolo: 3, volume: 50, anno: 2001,
pagine: 681 - 685
SICI:
0012-1797(200103)50:3<681:AGSFT2>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHROMOSOME 20Q; ASHKENAZI JEWS; MELLITUS MAPS; PIMA-INDIANS; WIDE SEARCH; SIB PAIRS; LINKAGE; GENE; MUTATIONS; POLYMORPHISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Permutt, MA Washington Univ, Sch Med, Div Metab, 660 S Euclid,Box 8127, StLouis, MO 63110 USA Washington Univ 660 S Euclid,Box 8127 St Louis MO USA 63110 SA
Citazione:
M.A. Permutt et al., "A genome scan for type 2 diabetes susceptibility loci in a genetically isolated population", DIABETES, 50(3), 2001, pp. 681-685

Abstract

A total of 896 individuals of Ashkenazi Jewish descent were ascertained inIsrael from 267 multiplex families, including 472 sib-pairs affected with type 2 diabetes. A genome-wide scan with average marker spacing of 9.5 cM revealed five regions on four chromosomes (4q, 8q, 14q, and 20q) that exhibited nominal evidence for linkage (P < 0.05). The highest observed nonparametric linkage Z score was 2.41 (equivalent to a logarithm of odds score of 1.26) at marker D4S1501. A maximal signal, with a Z score of 2.05, was observed on chromosome 20 near marker D20S195, and another on 20p near marker D20S103 (Z 1.80). A single marker on chromosome 8 (D8S593) and two adjacent markers on chromosome 14 (D14S749 and D14S605) also attained evidence of linkage. To explore the hypothesis that the signals on chromosomes 4 and 20 are differentially attributable to variation in BMI or age of onset, an ordered subset analysis was conducted. This analysis revealed that only when thefamilies were ranked by BMI tin increasing order) did a subset attain nominal significance, and only for chromosome 4. The findings reported here lend credence to the hypothesis, now supported by four studies of Caucasian populations and most recently by a combined analysis of 1,852 pedigrees, thata type 2 diabetes susceptibility locus resides on chromosome 20q. This population, because of its unique genetic attributes, may facilitate identification of this and other genes contributing to type 2 diabetes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 05:51:12