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Titolo:
Interplay between Cdc2 kinase and the c-Mos/MAPK pathway between metaphaseI and metaphase II in Xenopus oocytes
Autore:
Frank-Vaillant, M; Haccard, O; Ozon, R; Jessus, C;
Indirizzi:
Univ Paris 06, ESA CNRS 7080, INRA, Reprod Physiol Lab, F-75252 Paris, France Univ Paris 06 Paris France F-75252 od Physiol Lab, F-75252 Paris, France
Titolo Testata:
DEVELOPMENTAL BIOLOGY
fascicolo: 1, volume: 231, anno: 2001,
pagine: 279 - 288
SICI:
0012-1606(20010301)231:1<279:IBCKAT>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
MATURATION-PROMOTING FACTOR; PROTO-ONCOGENE PRODUCT; MAP KINASE; MEIOTIC MATURATION; CELL-CYCLE; TYROSINE PHOSPHORYLATION; MPF AMPLIFICATION; UBIQUITIN PATHWAY; MOS; EGGS;
Keywords:
Xenopus oocyte; c-Mos; Cdc2; cyclins; meiotic maturation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Jessus, C Univ Paris 06, ESA CNRS 7080, INRA, Reprod Physiol Lab, 4 Pl Jussieu,Boite13, F-75252 Paris, France Univ Paris 06 4 Pl Jussieu,Boite 13 Paris France F-75252 France
Citazione:
M. Frank-Vaillant et al., "Interplay between Cdc2 kinase and the c-Mos/MAPK pathway between metaphaseI and metaphase II in Xenopus oocytes", DEVELOP BIO, 231(1), 2001, pp. 279-288

Abstract

Xenopus oocytes arrested in prophase I resume meiotic division in responseto progesterone and arrest at metaphase II. Entry into meiosis I depends on the activation of Cdc2 kinase [M-phase promoting factor (MPF)]. To betterunderstand the role of Cdc2, MPF activity was specifically inhibited by injection of the CDK inhibitor, Cip1. When Cip1 is injected at germinal vesicle breakdown (GVBD) time, Cdc25 and Plx1 are both dephosphorylated and Cdc2is rephosphorylated on tyrosine. The autoamplification loop characterizingMPF is therefore not only required for MPF generation before GVBD, but also for its stability during the GVBD period. The ubiquitine ligase anaphase-promoting complex/cyclosome (APC/C), responsible for cyclin degradation, isalso under the control of Cdc2; therefore, Cdc2 activity itself induces its own inactivation through cyclin degradation, allowing the exit from the first meiotic division. In contrast, cyclin accumulation, responsible for Cdc2 activity increase allowing entry into metaphase II, is independent of Cdc2. The c-Mos/mitogen-activated protein kinase (MAPK) pathway remains active when Cdc2 activity is inhibited at GVBD time. This pathway could be responsible for the sustained cyclin neosynthesis. In contrast, during the metaphase II block, the c-Mos/MAPK pathway depends on Cdc2. Therefore, the metaphase II block depends on a dynamic interplay between MPF and CSF, the c-Mos/MAPK pathway stabilizing cyclin B, whereas in turn, MPF prevents c-Mos degradation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 21:18:19