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Titolo:
Normobaric hyperoxic stress in budgerigars: enzymic antioxidants and lipidperoxidation
Autore:
Jaensch, S; Cullen, L; Raidal, SR;
Indirizzi:
Murdoch Univ, Div Vet & Biomed Sci, Murdoch, WA 6150, Australia Murdoch Univ Murdoch WA Australia 6150 d Sci, Murdoch, WA 6150, Australia
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
fascicolo: 2, volume: 128, anno: 2001,
pagine: 173 - 180
SICI:
1532-0456(200102)128:2<173:NHSIBE>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
PULMONARY OXYGEN-TOXICITY; OXIDATIVE STRESS; FREE-RADICALS; DAMAGE; CHICK; RAT;
Keywords:
avian; oxygen toxicity; normobaric; glutathione; glutathione peroxidase; superoxide dismutase; isoprostane; lipid peroxidation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Jaensch, S Murdoch Univ, Div Vet & Biomed Sci, South St, Murdoch, WA 6150,Australia Murdoch Univ South St Murdoch WA Australia 6150 6150, Australia
Citazione:
S. Jaensch et al., "Normobaric hyperoxic stress in budgerigars: enzymic antioxidants and lipidperoxidation", COMP BIOC C, 128(2), 2001, pp. 173-180

Abstract

The effects of acute (3 h), repeated acute (3 exposures each of 3 h) and chronic (72 h) normobaric hyperoxic exposure in budgerigars (Melopsittacus undulatus) were evaluated by monitoring the effects on pulmonary enzymic antioxidants, and indicators of lipid peroxidation. All durations of oxygen exposure resulted in significant respiratory alkalosis and elevated pulmonaryand blood glutathione peroxidase concentrations. The concentrations of other pulmonary enzymic antioxidants including glutathione reductase and superoxide dismutase were not significantly altered by oxygen exposure. Pulmonary concentrations of the lipid peroxidation markers malonaldehyde and 4-hydroxyalkenal were not significantly elevated following oxygen exposure. Plasma concentrations of 8-epi isoprostane F-2 alpha were significantly elevatedfollowing both acute and repeated acute exposure. The results indicate that in budgerigars, both acute and chronic oxygen exposure can result in significant alteration in respiratory function and increased production of reactive oxygen species. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 01:03:19