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Titolo:
The influence of zinc on apical uptake of cadmium in the gills and cadmiuminflux to the circulatory system in zebrafish (Danio rerio)
Autore:
Glynn, AW;
Indirizzi:
Uppsala Univ, Dept Environm & Dev Biol, SE-75122 Uppsala, Sweden Uppsala Univ Uppsala Sweden SE-75122 Dev Biol, SE-75122 Uppsala, Sweden
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
fascicolo: 2, volume: 128, anno: 2001,
pagine: 165 - 172
SICI:
1532-0456(200102)128:2<165:TIOZOA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
WATER RAINBOW-TROUT; BRACHYDANIO-RERIO; PHOXINUS-PHOXINUS; CALCIUM-TRANSPORT; MINNOWS; CD-109; ELIMINATION; ADAPTATION; TURNOVER; FISH;
Keywords:
Cd; Zn; gills; epithelial cells; inhibition; chloride cells; metallothionein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Glynn, AW Swedish Natl Food Adm, Div Toxicol, POB 622, SE-75126 Uppsala, Sweden Swedish Natl Food Adm POB 622 Uppsala Sweden SE-75126 a, Sweden
Citazione:
A.W. Glynn, "The influence of zinc on apical uptake of cadmium in the gills and cadmiuminflux to the circulatory system in zebrafish (Danio rerio)", COMP BIOC C, 128(2), 2001, pp. 165-172

Abstract

Zn (0-16 muM) effects on apical Cd uptake from the water into the branchial epithelium and influx of Cd from the water to the circulatory system in zebrafish (Danio rerio) were studied in three experiments. Apical Cd uptake was decreased by Zn in all three experiments. In fish exposed to 1-600 nM Cd (experiment 1), apical Cd uptake showed saturation kinetics at 2 and 4 muM Zn, and a competitive interaction was indicated. At 16 muM Zn, Cd uptake increased linearly. Cadmium influx did not show saturation kinetics, but was inhibited by 16 muM Zn at low Cd exposure concentrations. In fish exposedto 0.1-600 nM Cd (experiment 2), Cd uptake was inhibited by 16 muM Zn, whereas at 30 nM Cd uptake was inhibited by 2 muM Zn. Similarly, 2 muM Zn did not influence Cd uptake in fish exposed to 0.1-2 nM Cd (experiment 3), whereas 2 muM Zn inhibited uptake at 8-30 nM Cd. Zinc also inhibited Cd influx at higher Cd concentrations. However, at lower Cd exposures, a Zn-induced increased influx was indicated. Zinc influences the Cd uptake and influx processes at several sites in the branchial epithelial cells, indicating that influx of Zn2+ and Cd2+ occurs through common pathways. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 14:09:15