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Titolo:
Tea catechins inhibit cholesterol oxidation accompanying oxidation of low density lipoprotein in vitro
Autore:
Osada, K; Takahashi, M; Hoshina, S; Nakamura, M; Nakamura, S; Sugano, M;
Indirizzi:
Hirosaki Univ, Fac Agr & Life Sci, Dept Appl Life Sci, Hirosaki, Aomori 0368561, Japan Hirosaki Univ Hirosaki Aomori Japan 0368561 rosaki, Aomori 0368561, Japan Asahikawa Med Coll, Dept Chem, Asahikawa, Hokkaido 0788510, Japan Asahikawa Med Coll Asahikawa Hokkaido Japan 0788510 kkaido 0788510, Japan Prefectural Univ Kumamoto, Fac Environm & Symbiot Sci, Kumamoto 8628502, Japan Prefectural Univ Kumamoto Kumamoto Japan 8628502 Kumamoto 8628502, Japan
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
fascicolo: 2, volume: 128, anno: 2001,
pagine: 153 - 164
SICI:
1532-0456(200102)128:2<153:TCICOA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
GREEN TEA; LIPID-PEROXIDATION; OXIDIZED CHOLESTEROL; SERUM COPPER; ANTIOXIDANT ACTIVITY; HUMAN PLASMA; RATS; METABOLISM; OXYSTEROLS; ABSORPTION;
Keywords:
antioxidation; catechin; cholesterol; lipoprotein; oxidation; oxidized cholesterol; oxygen radicals; polyphenol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Osada, K Hirosaki Univ, Fac Agr & Life Sci, Dept Appl Life Sci, 3 Bunkyo Cho, Hirosaki, Aomori 0368561, Japan Hirosaki Univ 3 Bunkyo Cho Hirosaki Aomori Japan 0368561 1, Japan
Citazione:
K. Osada et al., "Tea catechins inhibit cholesterol oxidation accompanying oxidation of low density lipoprotein in vitro", COMP BIOC C, 128(2), 2001, pp. 153-164

Abstract

Endogenous oxidized cholesterols are potent atherogenic agents. Therefore,the antioxidative effects of green tea catechins (GTC) against cholesteroloxidation were examined in an in vitro lipoprotein oxidation system. The antioxidative potency of GTC against copper catalyzed LDL oxidation was in the decreasing order(-)-epigalocatechin gallate (EGCG)= (-)-epicatechin gallate (ECG) > (-)-epicatechin (EC)=(+)-catechin (C) > (-)-epigallocatechin (EGC). Reflecting these activities, both EGCG (74%) and ECC (70%) inhibited the formation of oxidized cholesterol, as well as the decrease of linoleic and arachidonic acids, in copper catalyzed LDL oxidation. The formation of oxidized cholesterol in 2,2 '- azobis(2-amidinopropane) hydrochloride (AAPH)-mediated oxidation of rat plasma was also inhibited when the rats were given diets containing 0.5% ECG or EGCG. In addition, EGCG and ECG highly inhibited oxygen consumption and formation of conjugated dienes in AAPH-mediated linoleic acid peroxidative reaction. These two species of catechin also markedly lowered the generation of hydroxyl radical and superoxide anion. Thus, GTC, especially ECG and EGCG, seem to inhibit cholesterol oxidation in LDL by combination of interference with PUFA oxidation, the reduction and scavenging of copper ion, hydroxyl radical generated from peroxidation of PUFA and superoxide anion. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 07:17:16