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Titolo:
The genetic regulation of liver microsomal CYP2E1 activity among strains of the viviparous fish Poeciliopsis
Autore:
Kaplan, LAE; Fielding, E; Crivello, JF;
Indirizzi:
Univ Connecticut, Dept Physiol & Neurobiol, Storrs, CT 06269 USA Univ Connecticut Storrs CT USA 06269 ol & Neurobiol, Storrs, CT 06269 USA Teikyo Post Univ, Dept Environm Sci, Waterbury, CT USA Teikyo Post Univ Waterbury CT USA , Dept Environm Sci, Waterbury, CT USA Trinity Coll, Dept Biol, Hartford, CT 06106 USA Trinity Coll Hartford CT USA 06106 oll, Dept Biol, Hartford, CT 06106 USA
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
fascicolo: 2, volume: 128, anno: 2001,
pagine: 143 - 152
SICI:
1532-0456(200102)128:2<143:TGROLM>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
WINTER FLOUNDER; S-TRANSFERASE; TEMPERATURE; METABOLISM; CHLORZOXAZONE; EXPRESSION; BIOMARKER; INDUCTION;
Keywords:
cytochrome P450 2E1; Poeciliopsis; fish; genetics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Crivello, JF Univ Connecticut, Dept Physiol & Neurobiol, 3107 HorseBarn Hill Rd, Storrs, CT 06269 USA Univ Connecticut 3107 HorseBarn Hill Rd Storrs CT USA 06269 A
Citazione:
L.A.E. Kaplan et al., "The genetic regulation of liver microsomal CYP2E1 activity among strains of the viviparous fish Poeciliopsis", COMP BIOC C, 128(2), 2001, pp. 143-152

Abstract

CYP2E1 expression was examined within, among, and in F-1 and backcross progeny of strains (P. monacha S68-5; P. viriosa M65-23) of the viviparous fish Poeciliopsis. CYP 2E1 activity varied dramatically in P. monacha, and P. viriosa (3.9 +/- 0.8 and 9.6 +/- 1.3 mug/min/mg) as well as the temperaturewhich gave maximal activity (T-0 = 25 degreesC and 31 degreesC). F-1 individuals from a crosses between P. monacha and P. viriosa, produced progeny whose CYP2EI activity segregated into three different groups: (2) phenotypically the same as P. viriosa; (2) intermediate between the two parental strains and (3) phenotypically the same as P. monacha. When a male P. monacha was crossed with a female P. viriosa 25% of the offspring had an intermediate phenotype and 65% the maternal P. viriosa phenotype. From the same cross,85% of the females progeny had the maternal phenotype, while 80% of male progeny had the intermediate and paternal phenotype, suggesting an effect ofthe maternal genome on the F-1 phenotype. Among F-1 fish the T-0 was evenly distributed between parental values. In the backcross of a F-1 female to a male P. viriosa, CZX-6-hydroxylase activity segregated into the same three phenotypes with 60% of the progeny expressing the P. monacha phenotype. From the same cross, 70% of females and 40% of males expressed the P. monacha phenotype. The T-0 in the backcross were evenly distributed between the two parental values and the sex ratio among progeny was different than expected. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 23:11:27