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Titolo: A bifurcation analysis of two coupled calcium oscillators
Autore: Bindschadler, M; Sneyd, J;
 Indirizzi:
 Inst Informat & Math Sci, Auckland, New Zealand Inst Informat & Math Sci Auckland New Zealand ci, Auckland, New Zealand Univ Michigan, Dept Math, Ann Arbor, MI 48109 USA Univ Michigan Ann ArborMI USA 48109 , Dept Math, Ann Arbor, MI 48109 USA
 Titolo Testata:
 CHAOS
fascicolo: 1,
volume: 11,
anno: 2001,
pagine: 237  246
 SICI:
 10541500(200103)11:1<237:ABAOTC>2.0.ZU;2Y
 Fonte:
 ISI
 Lingua:
 ENG
 Soggetto:
 WAVEPROPAGATION; RAT HEPATOCYTES; CA2+ WAVES; CELLS; RECEPTOR; AGONIST; MODEL; MECHANISMS; ANTIPHASE;
 Tipo documento:
 Article
 Natura:
 Periodico
 Settore Disciplinare:
 Physical, Chemical & Earth Sciences
 Citazioni:
 31
 Recensione:
 Indirizzi per estratti:
 Indirizzo: Sneyd, J Inst Informat & Math Sci, Massey Univ Albany Campus,Private Bag 102904, Auckland, New Zealand Inst Informat & Math Sci Massey Univ Albany Campus,Private Bag 102904 Auckland New Zealand



 Citazione:
 M. Bindschadler e J. Sneyd, "A bifurcation analysis of two coupled calcium oscillators", CHAOS, 11(1), 2001, pp. 237246
Abstract
In many cell types, asynchronous or synchronous oscillations in the concentration of intracellular free calcium occur in adjacent cells that are coupled by gap junctions. Such oscillations are believed to underlie oscillatory intercellular calcium waves in some cell types, and thus it is important to understand how they occur and are modified by intercellular coupling. Using a previous model of intracellular calcium oscillations in pancreatic acinar cells, this article explores the effects of coupling two cells with a simple linear diffusion term. Depending on the concentration of a signal molecule, inositol (1,4,5)trisphosphate, coupling two identical cells by diffusion can give rise to synchronized inphase oscillations, as well as differentamplitude inphase oscillations and sameamplitude antiphase oscillations. Coupling two nonidentical cells leads to more complex behaviors such as cascades of period doubling and multiply periodic solutions. This study is a first step towards understanding the role and significance of the diffusion of calcium through gap junctions in the coordination of oscillatory calcium waves in a variety of cell types. (C) 2001 American Institute of Physics.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 09:46:04