Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Efficacy of heparin-coated stent in early setting of acute myocardial infarction
Autore:
Shin, EK; Son, JW; Sohn, MS; Jin, DK; Park, GS; Koh, KK; Ahn, TH; Choi, IS;
Indirizzi:
Gachon Univ, Gil Med Ctr, Div Cardiol, Namdong Ku, Inchon 405760, South Korea Gachon Univ Inchon South Korea 405760 ong Ku, Inchon 405760, South Korea
Titolo Testata:
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
fascicolo: 3, volume: 52, anno: 2001,
pagine: 306 - 312
SICI:
1522-1946(200103)52:3<306:EOHSIE>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; PALMAZ-SCHATZ STENTS; BALLOON ANGIOPLASTY; IMMEDIATE ANGIOPLASTY; ENDOVASCULAR STENTS; BENESTENT-II; PILOT TRIAL; IMPLANTATION; BIOCOMPATIBILITY; MULTICENTER;
Keywords:
heparin coating; stent; acute myocardial infarction; thrombosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Shin, EK Gachon Univ, Gil Med Ctr, Div Cardiol, Namdong Ku, 1198 Kuwol Dong, Inchon405760, South Korea Gachon Univ 1198 Kuwol Dong Inchon South Korea 405760 outh Korea
Citazione:
E.K. Shin et al., "Efficacy of heparin-coated stent in early setting of acute myocardial infarction", CATHET C IN, 52(3), 2001, pp. 306-312

Abstract

Primary stenting has been reported to he superior to balloon percutaneous transluminal coronary angioplasty (PTCA) in acute myocardial infarction (AMI) for recurrent ischemia, target lesion revascularization, and restenosis. However, concerns about early reocclusion or thrombosis after stenting in the very thrombotic environment of acute myocardial infarction still remain. Therefore, postprocedural short-term heparin or GpII(b)/IIIa receptor blockades has been used. The aim of our study was to evaluate the safety, feasibility and long-term efficacy of heparin-coated stent in the early settingof AMI without postprocedural heparin or GpII(b)/IIIa receptor blockade infusion. We studied 102 consecutive patients presenting to cardiac catheterization laboratory less than or equal to 6 hr from the onset of chest pain. No patients who were implanted with heparin-coated stents received heparin or GpII(b)/IIIa receptor blockade infusion after the procedures, not even patients who showed an angiographically large thrombus burden before stenting. Patients were evaluated for clinical endpoints at 30 days and 6 months. Coronary angiography was required for all patients at 2 weeks and 6 months after the procedure. Angiographic and procedural successes were 100% and 98%, respectively. Two patients (2%) died of heart failure without evidence of reocclusion of stented Vessel during the hospitalization and 4 (4%) additional patients died of refractory heart failure within the first 6 months. Major bleeding complication occurred in one patient (1%). Recurrent myocardial infarction developed in one patient at 4 months, Early angiographic follow up at 2 weeks was performed in 88% of all patients, none of whom showedthrombotic stent occlusion. Six-month angiographic follow-up was completedin 71%(64/91) of eligible patients and binary restenosis was present in 17.2% of stented vessels. Eight(8%) patients underwent repeat PTCA. Cardiac event-free survival rate at 6 months was 86.3%. This study demonstrates thatheparin-coated stents are safe in the early setting of acute myocardial infarction and no additional heparin infusion after stenting is necessary, which may reduce bleeding complications. Angiographic restenosis rate compares favorably to the binary restenosis rate from other studies with uncoated stents. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 22:16:39