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Titolo:
Increased expression of cyclooxygenase-2 protein in 4-nitroquinoline-1-oxide-induced rat tongue carcinomas and chemopreventive efficacy of a specificinhibitor, nimesulide
Autore:
Shiotani, H; Denda, A; Yamamoto, K; Kitayama, W; Endoh, T; Sasaki, Y; Tsutsumi, M; Sugimura, M; Konishi, Y;
Indirizzi:
Nara Med Univ, Dept Oncol Pathol, Ctr Canc, Kashihara, Nara 6348521, JapanNara Med Univ Kashihara Nara Japan 6348521 Kashihara, Nara 6348521, Japan Nara Med Univ, Dept Oral & Maxillofacial Surg, Kashihara, Nara 6348521, Japan Nara Med Univ Kashihara Nara Japan 6348521 Kashihara, Nara 6348521, Japan
Titolo Testata:
CANCER RESEARCH
fascicolo: 4, volume: 61, anno: 2001,
pagine: 1451 - 1456
SICI:
0008-5472(20010215)61:4<1451:IEOCPI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
SQUAMOUS-CELL CARCINOMA; COLON-CANCER; NECK-CANCER; HEAD; GROWTH; CARCINOGENESIS; TUMORS; SYNTHASE-2; RETINOIDS; PROSTAGLANDINS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Denda, A Nara Med Univ, Dept Oncol Pathol, Ctr Canc, 840 Shijo Cho, Kashihara, Nara6348521, Japan Nara Med Univ 840 Shijo Cho Kashihara Nara Japan 6348521 1, Japan
Citazione:
H. Shiotani et al., "Increased expression of cyclooxygenase-2 protein in 4-nitroquinoline-1-oxide-induced rat tongue carcinomas and chemopreventive efficacy of a specificinhibitor, nimesulide", CANCER RES, 61(4), 2001, pp. 1451-1456

Abstract

Expression of cyclooxygenase (COX)-2 protein in 4-nitroquinoline-loxide (4-NQO)-induced rat tongue lesions and the postinitiation chemopreventive potential of a selective COX-2 inhibitor, nimesulide (NIM), were examined in Fischer 344 male rats. NIM was administered in the diet at doses of 150, 300, and 600 ppm for 14 weeks after treatment with 25-35 ppm 4-NQO in the drinking water for 12 weeks. Western blot analysis revealed COX-2 protein to bebarely expressed in the normal tongue epithelia, whereas it was increased similar to6-fold in squamous cell carcinomas (SCCs). Immunohistochemically,COX-2 protein was diffusely present in SCCs and dysplasia but expressed only in basal cells in hyperplasia and papillomas. In basal cells of normal epithelia, it was also occasionally weakly stained. NIM dose-dependently decreased at doses of 150 and 300 ppm, the incidences of SCCs to 4 of 12 (33.3%) and 1 of 13 (7.7%) and their multiplicity to 0.33 +/- 0.49 and 0.08 +/- 0.28 per rat, respectively, as compared with 4-NQO alone group values of 9 of 11 (81.8%) and 1.00 +/- 0.77. A lesser decrease was observed with 600 ppm, the values being 5 of 12 (41.7%) and 0.50 +/- 0.67. NIM did not significantly affect the development of hyperplasias! dysplasias, and papillomas. These results clearly indicate chemopreventive potential of a selective COX-2 inhibitor against the postinitiation development of SCCs in rat tongue carcinogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 20:09:03