Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Apoptosis induction by the photosensitizer verteporfin: Identification of mitochondrial adenine nucleotide translocator as a critical target
Autore:
Belzacq, AS; Jacotot, E; Vieira, HLA; Mistro, D; Granville, DJ; Xie, ZH; Reed, JC; Kroemer, G; Brenner, C;
Indirizzi:
Burnham Inst, La Jolla, CA 92037 USA Burnham Inst La Jolla CA USA 92037Burnham Inst, La Jolla, CA 92037 USA QLT PhotoTherapeut Inc, Vancouver, BC V5Z 4H5, Canada QLT PhotoTherapeut Inc Vancouver BC Canada V5Z 4H5 er, BC V5Z 4H5, Canada Inst Gustave Roussy, CNRS, UMR 1599, F-94805 Villejuif, France Inst Gustave Roussy Villejuif France F-94805 , F-94805 Villejuif, France Univ Technol Compiegne, CNRS, UMR 6022, F-60205 Compiegne, France Univ Technol Compiegne Compiegne France F-60205 -60205 Compiegne, France
Titolo Testata:
CANCER RESEARCH
fascicolo: 4, volume: 61, anno: 2001,
pagine: 1260 - 1264
SICI:
0008-5472(20010215)61:4<1260:AIBTPV>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERMEABILITY TRANSITION PORE; DEPENDENT ANION CHANNEL; BCL-2 FAMILY PROTEINS; CYTOCHROME-C RELEASE; CELL-DEATH; PHOTODYNAMIC THERAPY; BENZODIAZEPINE RECEPTORS; ACTIVATION; BAX; OVEREXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Brenner, C Univ Technol Compiegne, CNRS, UMR 6022, BP20529, F-60205 Compiegne, France Univ Technol Compiegne BP20529 Compiegne France F-60205 France
Citazione:
A.S. Belzacq et al., "Apoptosis induction by the photosensitizer verteporfin: Identification of mitochondrial adenine nucleotide translocator as a critical target", CANCER RES, 61(4), 2001, pp. 1260-1264

Abstract

We report that the photosensitizer verteporfin kills lymphoma cells by an apoptotic process involving a dissipation of the mitochondrial inner transmembrane potential (Delta Psim). Light-activated verteporfin-induced apoptosis was abolished by transfection with Bcl-2, a procedure reported to inhibit the mitochondrial permeability transition pore complex (PTPC). Verteporfin triggered the Delta Psim loss in isolated mitochondria in vitro, and thiseffect was suppressed by bongrekic acid and cyclosporin A. Verteporfin plus light also permeabilized proteoliposomes containing the semipurified PTPCor the purified PTPC component adenine nucleotide translocator (ANT), yet had no effect on protein-free control liposomes. Verteporfin phototoxicity on ANT proteoliposomes was mediated by reactive oxygen species and mas prevented by recombinant Bcl-2 or the adenine nucleotides ATP and ADP. In conclusion, verteporfin belongs to a class of clinically used chemotherapeutic agents acting on PTPC and ANT.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 18:28:46