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Titolo:
Potentiation of the antinociceptive effect of clomipramine by a 5-ht(1A) antagonist in neuropathic pain in rats
Autore:
Ardid, D; Alloui, A; Brousse, G; Jourdan, D; Picard, P; Dubray, C; Eschalier, A;
Indirizzi:
Fac Med, Lab Pharmacol Med, INSERM EPI 9904, F-63001 Clermont Ferrand, France Fac Med Clermont Ferrand France F-63001 F-63001 Clermont Ferrand, France CHU, Ctr Evaluat & Traitement Douleur, F-63001 Clermont Ferrand, France CHU Clermont Ferrand France F-63001 ur, F-63001 Clermont Ferrand, France
Titolo Testata:
BRITISH JOURNAL OF PHARMACOLOGY
fascicolo: 5, volume: 132, anno: 2001,
pagine: 1118 - 1126
SICI:
0007-1188(200103)132:5<1118:POTAEO>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
5-HT1A RECEPTOR ANTAGONISTS; INDUCED DIABETIC RATS; FRONTAL-CORTEX; ANTIDEPRESSANT DRUGS; EXTRACELLULAR 5-HYDROXYTRYPTAMINE; PERIPHERAL MONONEUROPATHY; AUTORECEPTOR BLOCKADE; REUPTAKE INHIBITORS; BEHAVIORAL EVIDENCE; MAJOR DEPRESSION;
Keywords:
antidepressant; clomipramine; neuropathic pain; 5-HT1A antagonist; antinociception; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Ardid, D Fac Med, Lab Pharmacol Med, INSERM EPI 9904, F-63001 Clermont Ferrand, France Fac Med Clermont Ferrand France F-63001 lermont Ferrand, France
Citazione:
D. Ardid et al., "Potentiation of the antinociceptive effect of clomipramine by a 5-ht(1A) antagonist in neuropathic pain in rats", BR J PHARM, 132(5), 2001, pp. 1118-1126

Abstract

1 The benefit of antidepressant treatment in human neuropathic pain is nowwell documented, but the effect is limited and slow to appear. It has beendemonstrated that the association of a 5-HT1A antagonist and a serotoninergic antidepressant reduced the delay of action and increases the thymoanaleptic effect of the drug.2 The purpose of this work was to evaluate the combination of an antidepressant and a 5-HT1A antagonist in animal models of chronic neuropathic pain. We studied the antinociceptive effect of the co-administration of clomipramine and a 5-HT1A antagonist (WAY 100,635) in a pain test applied in normalrats and in two models of neurogenic sustained pain (mononeuropathic and diabetic rats).3 The results show an increase in the antinociceptive effect of acutely injected clomipramine due to WAY 100,635 in these models, which is majored when the two drugs are repeatedly injected. The 5-HT1A antagonist reduced thedelay of onset and increased the maximal antinociceptive effect of clomipramine.4 These new findings argue for using the combination of an antidepressant and a 5-HT1A antagonist in human neuropathic pain therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:37:51