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Titolo:
Gene therapy for carcinoma of the breast - Pro-apoptotic gene therapy
Autore:
Gomez-Navarro, J; Arafat, W; Xiang, JL;
Indirizzi:
Univ Alabama, Gene Therapy Ctr, Lurleen B Wallace Tumor Inst 602, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 r Inst 602, Birmingham, AL 35294 USA Univ Alabama, Dept Hematol Oncol, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 atol Oncol, Birmingham, AL 35294 USA Univ Chicago, Ben May Inst Canc Res, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637 ay Inst Canc Res, Chicago, IL 60637 USA
Titolo Testata:
BREAST CANCER RESEARCH
fascicolo: 1, volume: 2, anno: 2000,
pagine: 32 - 44
SICI:
1465-542X(2000)2:1<32:GTFCOT>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
WILD-TYPE P53; SELECTIVELY INDUCES APOPTOSIS; TUMOR-SUPPRESSOR GENE; PROGRAMMED CELL-DEATH; TAMOXIFEN-INDUCED APOPTOSIS; SINGLE-CHAIN ANTIBODY; OVARIAN-CANCER CELLS; HEAT-SHOCK PROTEINS; BCL-X-L; IN-VIVO;
Keywords:
breast cancer; gene therapy; apoptosis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
141
Recensione:
Indirizzi per estratti:
Indirizzo: Gomez-Navarro, J Univ Alabama, Gene Therapy Ctr, Lurleen B Wallace Tumor Inst 602, 1824 6thAve S, Birmingham, AL 35294 USA Univ Alabama 1824 6th Ave S Birmingham AL USA 35294 4 USA
Citazione:
J. Gomez-Navarro et al., "Gene therapy for carcinoma of the breast - Pro-apoptotic gene therapy", BREAST CA R, 2(1), 2000, pp. 32-44

Abstract

The dysregulation of apoptosis contributes in a variety of ways to the malignant phenotype. It is increasingly recognized that the alteration of pro-apoptotic and anti-apoptotic molecules determines not only escape from mechanisms that control cell cycle and DNA damage, but also endows the cancer cells with the capacity to survive in the presence of a metabolically adverse milieu, to resist the attack of the immune system, to locally invade and survive despite a lack of tissue anchorage, and to evade the otherwise lethal insults induced by drugs and radiotherapy. A multitude of apoptosis mediators has been identified in the past decade, and the roles of several of them in breast cancer have been delineated by studying the clinical correlates of pathologically documented abnormalities. Using this information, attempts are being made to correct the fundamental anomalies at the genetic level. Fundamental to this end are the design of more efficient and selective gene transfer systems, and the employment of complex interventions that aretailored to breast cancer and that are aimed concomitantly towards different components of the redundant regulatory pathways. The combination of suchgenetic modifications is most likely to be effective when combined with conventional treatments, thus robustly activating several pro-apoptotic pathways.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/06/20 alle ore 06:47:32