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Titolo:
Tyrosine kinase signalling in breast cancer - Modulation of tyrosine kinase signalling in human breast cancer through altered expression of signalling intermediates
Autore:
Kairouz, R; Daly, RJ;
Indirizzi:
St Vincents Hosp, Garvan Inst Med Res, Canc Res Program, Sydney, NSW 2010,Australia St Vincents Hosp Sydney NSW Australia 2010 am, Sydney, NSW 2010,Australia
Titolo Testata:
BREAST CANCER RESEARCH
fascicolo: 3, volume: 2, anno: 2000,
pagine: 197 - 202
SICI:
1465-542X(2000)2:3<197:TKSIBC>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMAL GROWTH-FACTOR; PP60C-SRC PROTEIN-KINASE; TUMOR CELL-LINES; INSULIN-RECEPTOR; PLECKSTRIN HOMOLOGY; SIGNALING PATHWAYS; CONTACT SITES; SH2 DOMAIN; GRB2 GENE; EMS1 GENE;
Keywords:
breast cancer; SH2 domain; SH3 domain; signal transduction; tyrosine kinase;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Daly, RJ St Vincents Hosp, Garvan Inst Med Res, Canc Res Program, Sydney, NSW 2010,Australia St Vincents Hosp Sydney NSW Australia 2010 y, NSW 2010,Australia
Citazione:
R. Kairouz e R.J. Daly, "Tyrosine kinase signalling in breast cancer - Modulation of tyrosine kinase signalling in human breast cancer through altered expression of signalling intermediates", BREAST CA R, 2(3), 2000, pp. 197-202

Abstract

The past decade has seen the definition of key signalling pathways downstream of receptor tyrosine kinases (RTKs) in terms of their components and the protein-protein interactions that facilitate signal transduction. Given the strong evidence that links signalling by certain families of RTKs to theprogression of breast cancer, it is not surprising that the expression profile of key downstream signalling intermediates in this disease has also come under scrutiny, particularly because some exhibit transforming potentialor amplify mitogenic signalling pathways when they are overexpressed. Reflecting the diverse cellular processes regulated by RTKs, it is now clear that altered expression of such signalling proteins in breast cancer may influence not only cellular proliferation (eg Grb2) but also the invasive properties of the cancer cells (eg EMS1/cortactin).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 19:38:48