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Titolo:
Molecular biology of breast cancer metastasis - Molecular expression of vascular markers by aggressive breast cancer cells
Autore:
Hendrix, MJC; Seftor, EA; Kirschmann, DA; Seftor, REB;
Indirizzi:
Univ Iowa, Coll Med, Dept Anat & Cell Biol, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 nat & Cell Biol, Iowa City, IA 52242 USA Univ Iowa, Ctr Canc, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 Iowa, Ctr Canc, Iowa City, IA 52242 USA
Titolo Testata:
BREAST CANCER RESEARCH
fascicolo: 6, volume: 2, anno: 2000,
pagine: 417 - 422
SICI:
1465-542X(2000)2:6<417:MBOBCM>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; TUMOR ANGIOGENESIS; VASCULOGENIC MIMICRY; PROGNOSTIC INDICATOR; BLOOD-FLOW; HUMAN CYTOTROPHOBLASTS; ENDOVASCULAR INVASION; THROMBIN RECEPTOR; UVEAL MELANOMA; PHENOTYPE;
Keywords:
breast cancer; interconverted phenotype; thrombin receptor; TIE2;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Hendrix, MJC Univ Iowa, Coll Med, Dept Anat & Cell Biol, 51 Newton Rd 1-100 BSB, Iowa City, IA 52242 USA Univ Iowa 51 Newton Rd 1-100 BSB Iowa City IA USA 52242 2 USA
Citazione:
M.J.C. Hendrix et al., "Molecular biology of breast cancer metastasis - Molecular expression of vascular markers by aggressive breast cancer cells", BREAST CA R, 2(6), 2000, pp. 417-422

Abstract

During embryogenesis, the formation of primary vascular networks occurs via the processes of vasculogenesis and angiogenesis. In uveal melanoma, vasculogenic mimicry describes the 'embryonic-like' ability of aggressive, but not nonaggressive, tumor cells to form networks surrounding spheroids of tumor cells in three-dimensional culture; these recapitulate the patterned networks seen in patients' aggressive tumors and correlates with poor prognosis. The molecular profile of these aggressive tumor cells suggests that they have a deregulated genotype, capable of expressing vascular phenotypes. Similarly, the embryonic-like phenotype expressed by the aggressive human breast cancer cells is associated with their ability to express a variety of vascular markers. These studies may offer new insights for consideration inbreast cancer diagnosis and therapeutic intervention strategies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 13:40:14