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Titolo:
Syk: a new player in the field of breast cancer
Autore:
Stewart, ZA; Pietenpol, JA;
Indirizzi:
Vanderbilt Univ, Sch Med, Ctr Mol Toxicol, Dept Biochem, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 t Biochem, Nashville, TN 37232 USA Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 Canc Ctr, Nashville, TN 37232 USA
Titolo Testata:
BREAST CANCER RESEARCH
fascicolo: 1, volume: 3, anno: 2001,
pagine: 5 - 7
SICI:
1465-542X(2001)3:1<5:SANPIT>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR-MEDIATED ACTIVATION; PROTEIN-TYROSINE KINASE; B-LYMPHOCYTES; CELLS; PHOSPHORYLATION; IDENTIFICATION; MICE; AKT;
Keywords:
metastasis; murine xenograft tumors; nonreceptor tyrosine kinase;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Pietenpol, JA Vanderbilt Univ, Sch Med, Ctr Mol Toxicol, Dept Biochem, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 hville, TN 37232 USA
Citazione:
Z.A. Stewart e J.A. Pietenpol, "Syk: a new player in the field of breast cancer", BREAST CA R, 3(1), 2001, pp. 5-7

Abstract

Breast tumor development and progression are thought to occur through a complex, multistep process, including oncogene activation (eg HER2/neu) and mutation or loss of tumor suppressor genes (eg p53). Determining the function of genetic alterations in breast carcinoma tumorigenesis and metastasis has been the focus of intensive research efforts for several decades. One group of proteins that play a critical role in breast cancer cell signaling pathways are tyrosine kinases. Overexpression of the tyrosine kinase HER2/neu is observed in many human breast cancers and is positively correlated with enhanced tumorigenesis [1]. Recently, another tyrosine kinase, Syk, has been implicated as an important inhibitor of breast cancer cell growth and metastasis [2]. This recent finding was unexpected, since Syk function has been predominantly linked to hematopoietic cell signaling, and is discussed further in this commentary.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:52:30