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Titolo:
Protective effect of quinacrine on striatal dopamine levels in 6-OHDA and MPTP models of Parkinsonism in rodents
Autore:
Tariq, M; Khan, HA; Al Moutaery, K; Al Deeb, S;
Indirizzi:
Armed Forces Hosp, Res Ctr, Neurosci Res Grp, Riyadh 11159, Saudi Arabia Armed Forces Hosp Riyadh Saudi Arabia 11159 , Riyadh 11159, Saudi Arabia
Titolo Testata:
BRAIN RESEARCH BULLETIN
fascicolo: 1, volume: 54, anno: 2001,
pagine: 77 - 82
SICI:
0361-9230(20010101)54:1<77:PEOQOS>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOSOLIC PHOSPHOLIPASE A(2); EXCITATORY AMINO-ACIDS; RAT CEREBRAL-CORTEX; ARACHIDONIC-ACID; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE MPTP; 6-HYDROXYDOPAMINE TOXICITY; INTRASTRIATAL INJECTION; GLUTATHIONE DEPLETION; INDUCED NEUROTOXICITY; SIGNAL-TRANSDUCTION;
Keywords:
parkinsonism; phospholipase; 6-OHDA; MPTP; oxidative stress; dopamine; glutathione;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
79
Recensione:
Indirizzi per estratti:
Indirizzo: Tariq, M Armed Forces Hosp, Res Ctr, Neurosci Res Grp, POB 7897 W-912, Riyadh 11159, Saudi Arabia Armed Forces Hosp POB 7897 W-912 Riyadh Saudi Arabia 11159 rabia
Citazione:
M. Tariq et al., "Protective effect of quinacrine on striatal dopamine levels in 6-OHDA and MPTP models of Parkinsonism in rodents", BRAIN RES B, 54(1), 2001, pp. 77-82

Abstract

Recent studies provide evidence that phospholipase A(2) (PLA(2)) may play a role in the development of experimental parkinsonism. In this investigation an attempt was made to determine a possible protective effect of quinacrine (QNC), a PLA(2) inhibitor on MPTP as well as 6-hydroxydopamine (6-OHDA)-induced neurotoxicity in rodents. For MPTP studies, adult male mice (C57 BL) were treated with MPTP (30 mg/kg, i.p.) daily for 5 days. QNC was injected i.p. in the doses of 0, 10, 30 and 60 mg/kg daily 30 min before MPTP in four different groups. Two other groups of mice received either vehicle (control) or a high dose of QNC (60 mg/kg). Two hours after the last injectionof MPTP, striata were collected for the analysis of dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and glutathione (GSH). For the 6-OHDA study, mate Wistar rats were infused with 6-OHDA (60 mug) in the right striatum under chloral hydrate anesthesia. The rats in different groups were treated with 0, 5, 15 and 30 mg/kg QNC (i.p.) for 4 days,while first injection was given 30 min before 6-OHDA. On day 5, rats were sacrificed and striata were stored at -80 degreesC. Administration of MPTP or 6-OHDA significantly reduced striatal DA, which was significantly attenuated by QNC. Concomitant treatment with QNC also protected animals against MPTP or 6-OHDA-induced depletion of striatal GSH. Our findings clearly suggest the role of PLA(2) in MPTP and 6-OHDA induced neurotoxicity and oxidative stress. However, further studies are warranted to explore the therapeutic potential of PLA, inhibitors for the treatment of Parkinson's disease. (C) 2001 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/06/19 alle ore 17:08:13