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Titolo:
Role of PAG in the antinociception evoked from the medial or central amygdala in rats
Autore:
Oliveira, MA; Prado, WA;
Indirizzi:
Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Pharmacol, BR-14049900 Sao Paulo, Brazil Univ Sao Paulo Sao Paulo Brazil BR-14049900 BC14049900 Sao Paulo, Brazil
Titolo Testata:
BRAIN RESEARCH BULLETIN
fascicolo: 1, volume: 54, anno: 2001,
pagine: 55 - 63
SICI:
0361-9230(20010101)54:1<55:ROPITA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
MIDBRAIN PERIAQUEDUCTAL GRAY; ROSTRAL VENTROMEDIAL MEDULLA; RECEPTOR MESSENGER-RNA; CENTRAL NUCLEUS; BRAIN-STEM; AMYGDALOSPINAL PROJECTIONS; MORPHINE ANTINOCICEPTION; CONDITIONAL HYPOALGESIA; HYPOTHALAMIC NEURONS; IDENTIFIED SITES;
Keywords:
antinociception; amygdala; periaqueductal gray; stimulation-produced antinociception; medial nucleus of the amygdala; central nucleus of the amygdala;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Prado, WA Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Pharmacol, BR-14049900 Sao Paulo, Brazil Univ Sao Paulo Sao Paulo Brazil BR-14049900 BCao Paulo, Brazil
Citazione:
M.A. Oliveira e W.A. Prado, "Role of PAG in the antinociception evoked from the medial or central amygdala in rats", BRAIN RES B, 54(1), 2001, pp. 55-63

Abstract

The effects of stimulating the periaqueductal gray (PAG) against the rat tail flick reflex (TFR) was not changed significantly by the microinjection of lidocaine (5%/0.5 mul) into the medial (ME) or central (CE) nuclei of the amygdala. In contrast, lidocaine into the PAG blocked the effects from the ME or CE. The microinjection of naloxone (1 mug), beta -funaltrexamine (2mug), propranolol (1 mug), or methysergide (1 mug), but not atropine (1 mug) or mecamylamine (1 mug) into the PAG significantly reduced the effects from the CE. The effect from the ME was not altered significantly by microinjecting naloxone into the PAG. Therefore, the ME or CE are unlikely to be intermediary stations for depression of the TFR evoked by stimulating the PAG, but the PAG may be a relay station for the effects of stimulating the MEor CE. The circuitry activated from the CE, but not the ME, utilises opioid mediation in the PAG. The effect from the CE depends at least on mu -opioid, serotonergic, and probably beta -adrenergic mediation in the PAG. (C) 2001 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:27:41