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Titolo:
Microinjection of a 5-HT3 receptor agonist into the NTS of awake rats inhibits the bradycardic response to activation of the von Bezold-Jarisch reflex
Autore:
Leal, DM; Callera, JC; Bonagamba, LGH; Nosjean, A; Laguzzi, R; Machado, BH;
Indirizzi:
Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Physiol, BR-14049900 Sao Paulo, Brazil Univ Sao Paulo Sao Paulo Brazil BR-14049900 BC14049900 Sao Paulo, Brazil CHU Pitie Salpetriere, INSERM, Paris, France CHU Pitie Salpetriere ParisFrance e Salpetriere, INSERM, Paris, France
Titolo Testata:
BRAIN RESEARCH BULLETIN
fascicolo: 1, volume: 54, anno: 2001,
pagine: 7 - 11
SICI:
0361-9230(20010101)54:1<7:MOA5RA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS-TRACTUS-SOLITARIUS; BARORECEPTOR REFLEX; CONSCIOUS RATS; GABA(B) RECEPTORS; L-GLUTAMATE; STIMULATION;
Keywords:
C-fiber; cardiopulmonary receptor; serotonin(3) receptor; 2-methyl-5-HT; NTS; bradycardia; sympatho-inhibition; serotonin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Machado, BH Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Physiol, BR-14049900 Sao Paulo, Brazil Univ Sao Paulo Sao Paulo Brazil BR-14049900 BC Paulo, Brazil
Citazione:
D.M. Leal et al., "Microinjection of a 5-HT3 receptor agonist into the NTS of awake rats inhibits the bradycardic response to activation of the von Bezold-Jarisch reflex", BRAIN RES B, 54(1), 2001, pp. 7-11

Abstract

In the present study we investigated the effects of bilateral microinjection into the lateral commissural nucleus tractus solitarius (NTS) of 2-methyl-5-HT, a 5-HT3 receptor agonist, on the bradycardic response of the von Bezold-Jarisch reflex of awake rats. We evaluated mainly the bradycardic response because in previous studies we documented that the hypotensive response of the von-Bezold-Jarisch reflex in awake rats is secondary to the intense bradycardic response. The Bezold-Jarisch reflex was activated by intravenous injection of serotonin (8 mug/kg) in awake rats before and 1, 3, 10, 20and 60 min after bilateral microinjection of 2-methyl-5-HT (5 nmol/50 nl, n = 8) into the NTS. Microinjections of 2-methyl-5-HT into the NTS produceda significant increase in basal mean arterial pressure [(MAP), 97 +/- 4 vs. 114 +/- 4 mmHg), no changes in basal heart rate and a significant reduction in bradycardic (-78 +/- 19; -94 +/- 24 and -107 +/- 21 bpm) and hypotensive (-16 +/- 4; -10 +/- 5 and -17 +/- 4 mmHg) responses to activation of the von Bezold-Jarisch reflex at 3, 10 and 20 min, respectively, when compared with the control value (-231 +/- 13 bpm and -43 +/- 4 mmHg). The data of the present study suggest that serotonin acting on 5-HT3 receptors in the NTS may play an important inhibitory neuromodulatory role in the bradycardicresponse to activation of the von Bezold-Jarisch reflex. (C) 2001 ElsevierScience Inc.

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Documento generato il 03/06/20 alle ore 09:11:23