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Titolo:
Inhibitory activity of berberine on DNA strand cleavage induced by hydrogen peroxide and cytochrome c
Autore:
Choi, DS; Kim, SJ; Jung, MY;
Indirizzi:
Woosuk Univ, Div Food Sci & Technol, Wanju Jun 565701, Jeonbuk Provinc, South Korea Woosuk Univ Wanju Jun Jeonbuk Provinc South Korea 565701 inc, South Korea Woosuk Univ, Div Biosci & Biotechnol, Wanju Jun 565701, Jeonbuk Provinc, South Korea Woosuk Univ Wanju Jun Jeonbuk Provinc South Korea 565701 inc, South Korea
Titolo Testata:
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
fascicolo: 2, volume: 65, anno: 2001,
pagine: 452 - 455
SICI:
0916-8451(200102)65:2<452:IAOBOD>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
COPTIS-JAPONICA MAKINO; SENSITIZED PHOTOOXIDATION; CELLS; RIBOFLAVIN;
Keywords:
berberine; DNA strand cleavage; hydrogen peroxide; cytochrome c; superoxide anion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Jung, MY Woosuk Univ, Div Food Sci & Technol, Samrae Up, Wanju Jun 565701,Jeonbuk Provinc, South Korea Woosuk Univ Samrae Up Wanju Jun Jeonbuk Provinc South Korea 565701
Citazione:
D.S. Choi et al., "Inhibitory activity of berberine on DNA strand cleavage induced by hydrogen peroxide and cytochrome c", BIOS BIOT B, 65(2), 2001, pp. 452-455

Abstract

The inhibitory activity of berberine on the DNA single-strand cleavage induced by hydrogen peroxide and cytochrome c was measured. Berberine effectively inhibited single-strand cleavage of DNA and its effectiveness was concentration-dependent. As the berberine concentration increased, the inhibitory activity against the DNA single-strand cleavage increased. The treatmentswith 1, 5, 10, 50, and 100 muM berberine showed 7.7, 10.8, 32.2, 39.5, and51.6% inhibition of DNA cleavage. This inhibitory activity of berberine against the DNA single-strand cleavage has never been reported previously. The inhibitory activity of berberine against DNA cleavage was stronger than caffeic acid and ascorbic acid. Berberine did not show strong hydroxyl radical scavenging activity, but showed strong superoxide anion radical quenching ability.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 16:07:02